Overview of the compromised mucosal integrity in celiac disease

被引：0
作者：
Tannaz Taraz
Mohadeseh Mahmoudi-Ghehsareh
Nastaran Asri
Ehsan Nazemalhosseini-Mojarad
Mostafa Rezaei-Tavirani
Somayeh Jahani-Sherafat
Ali Naseh
Mohammad Rostami-Nejad
机构：
[1] Shahid Beheshti University of Medical Sciences,Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases
[2] Shahid Beheshti University of Medical Sciences,Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases
[3] Shahid Beheshti University of Medical Sciences,Celiac Disease and Gluten Related Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases
[4] Shahid Beheshti University of Medical Sciences,Proteomics Research Center, Faculty of Paramedical Sciences
[5] Shahid Beheshti University of Medical Sciences,Laser Application in Medical Sciences Research Center
[6] Mahdiyeh Educational Hospital,Department of Pediatrics and Neonatology, Clinical Research Development Center
[7] Shahid-Beheshti University of Medical Sciences,undefined
来源：
Journal of Molecular Histology | 2024年 / 55卷
关键词：
Celiac Disease; Cell polarity; Intercellular junctions; Intestinal epithelium;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Intestinal epithelium is a dynamic cellular layer that lines the small-bowel and makes a relatively impenetrable barrier to macromolecules. Intestinal epithelial cell polarity is crucial in coordinating signalling pathways within cells and mainly regulated by three conserved polarity protein complexes, the Crumbs (Crb) complex, partitioning defective (PAR) complex, and Scribble (Scrib) complex. Polarity proteins regulate the proper establishment of the intercellular junctional complexes including tight junctions (TJs), adherence junctions (AJs), and desmosomes which hold epithelial cells together and play a major role in maintaining intestinal barrier integrity. Impaired intestinal epithelial cell polarity and barrier integrity result in irreversible immune responses, the host- microbial imbalance and intestinal inflammatory disorders. Disassembling the epithelial tight junction and augmented paracellular permeability is a conspicuous hallmark of celiac disease (CD) pathogenesis. There are several dietary components that can improve intestinal integrity and function. The aim of this review article is to summarize current information about the association of polarity proteins and AJC damages with pathogenesis of CD.
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页码：15 / 24
页数：9
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