Biodegradable porous scaffolds for tissue engineering

被引：2

作者：

Tateishi T. ^{[1
,2
]}

Chen G. ^{[2
]}

Ushida T. ^{[1
,2
]}

机构：

[1] Biomedical Engineering Laboratory, Graduate School of Engineering, University of Tokyo, Bunkyo-ku, Tokyo 113-8656

[2] Tissue Engineering Research Center, National Institute of Advanced Industrial Science and Technology, Tsukuba

来源：

Journal of Artificial Organs | 2002年 / 5卷 / 2期

关键词：

Biodegradable; Biomaterials; Scaffold; Tissue engineering;

D O I：

10.1007/s100470200014

中图分类号：

学科分类号：

摘要：

Three-dimensional scaffolds play an important role in tissue engineering as an adhesive substrate for implanted cells and a physical support to guide the formation of new organs. The scaffolds should facilitate cell adhesion, promote cell growth, allow the retention of differentiated cell functions, and be biocompatible, biodegradable, highly porous with a large surface-to-volume ratio, mechanically strong, and malleable. A number of biodegradable three-dimensional scaffolds have been developed for tissue engineering. This paper reviews some of the recent events in the development of these scaffolds.

引用

页码：77 / 83

页数：6

共 40 条

[1]

Langer R., Vacanti J.P., Tissue engineering, Science, 260, pp. 920-926, (1993)

[2]

Nerem R.M., Sambanis A., Tissue engineering: From biology to biological substitutes, Tissue Eng, 1, pp. 3-13, (1995)

[3]

Freed L.E., Marquis J.C., Nohria A., Emmanual J., Mikos A.C., Langer R., Neocartilage formation in vitro and in vivo using cells cultured on synthetic biodegradable polymers, J Biomed Mater Res, 27, pp. 11-23, (1993)

[4]

Freed L.E., Grande D.A., Lingbin Z., Emmanual J., Marquis J.C., Langer R., Joint resurfacing using allograft chondrocytes and synthetic biodegradable polymer scaffolds, J Biomed Mater Res, 28, pp. 891-899, (1994)

[5]

Cao Y., Vacanti J.P., Paige K.T., Upton J., Vacanti C.A., Transplantation of chondrocytes utilizing a polymer-cell construct to produce tissue-engineering cartilage in the shape of a human ear, Plast Reconstr Surg, 100, pp. 297-302, (1997)

[6]

Sims C.D., Butler P.E.M., Cao Y.L., Casanova R., Randolph M.A., Black A., Vacanti C.A., Yaremchuk M.J., Tissue engineered neocartilage using plasma derived polymer substrates and chondrocytes, Plast Reconstr Surg, 101, pp. 1580-1585, (1998)

[7]

Ishaug S.L., Crane G.M., Miller M.J., Yasko A.W., Yaszemski M.J., Mikos A.G., Bone formation by three-dimensional stromal osteoblast culture in biodegradable polymer scaffolds, J Biomed Mater Res, 36, pp. 17-28, (1997)

[8]

Zacchi V., Soranzo C., Cortivo R., Radice M., Brun P., Abatangelo G., In vitro engineering of human skin-like tissue, J Biomed Mater Res, 40, pp. 187-194, (1998)

[9]

Lin V.S., Lee M.C., O'Neal S., McKean J., Sung K.L.P., Ligament tissue engineering using synthetic biodegradable fiber scaffolds, Tissue Eng, 5, pp. 443-451, (1999)

[10]

Dunn M.G., Liesch J.B., Tiku M.L., Zawadsky J.P., Development of fibroblast-seeded ligament analogs for ACL reconstruction, J Biomed Mater Res, 29, pp. 1363-1371, (1995)

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