Oxidative Stress is a Convincing Contributor to Idiopathic Chronic Fatigue

被引：0
作者：
Jin-Seok Lee
Hyeong-Geug Kim
Dong-Soo Lee
Chang-Gue Son
机构：
[1] Dunsan Hospital of Daejeon University,Liver and Immunology Research Center
[2] Daejeon St. Mary’s Hospital,Department of Internal Medicine
[3] The Catholic University of Korea,undefined
来源：
Scientific Reports | / 8卷
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摘要：
The linkage between oxidative stress and idiopathic chronic fatigue (ICF) has not been explored in detail. This study thoroughly compared the serum levels of biomarkers for oxidative stress and antioxidants from 103 subjects with ICF (20 men and 83 women) to those of 82 healthy volunteers (27 men and 55 women). Oxidative parameters, which included reactive oxygen species (ROS), malondialdehyde (MDA) and F2-isoprotan, and tumor necrosis factor-alpha (TNF-α) were significantly elevated, while antioxidant parameters, which included total antioxidant activity (TAC), catalase, superoxide dismutase, SOD and GSH activity, were decreased compared to those of healthy subjects (by approximately 1.2- to 2.3-fold, p < 0.05 or 0.01). Our results confirmed that oxidative stress is a key contributor in the pathophysiology of ICF, and firstly explored the features of oxidative stress parameters in ICF subjects compared to a healthy population.
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[1]  
Wong WS(2010)Prevalence of chronic fatigue among Chinese adults in Hong Kong: a population-based study J Affect Disord 127 248-56
[2]  
Fielding R(2008)The epidemiology of chronic fatigue, physical illness, and symptoms of common mental disorders: a cross-sectional survey from the second British National Survey of Psychiatric Morbidity J Psychosom Res 64 357-62
[3]  
Watanabe N(2008)Chronic fatigue: an evolutionary concept analysis J Adv Nurs 63 199-207
[4]  
Stewart R(2013)narrative review on the similarities and dissimilarities between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and sickness behavior BMC Med 11 1009-18
[5]  
Jenkins R(2011)Biological mechanisms of chronic fatigue Rheumatology (Oxford). 50 75-83
[6]  
Bhugra DK(2009)Inflammatory and oxidative and nitrosative stress pathways underpinning chronic fatigue, somatization and psychosomatic symptoms Curr Opin Psychiatry. 22 SC11-5
[7]  
Furukawa TA(2011)Increased plasma peroxides as a marker of oxidative stress in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) Med SciMonit. 17 35-41
[8]  
Jorgensen R(2000)Blood parameters indicative of oxidative stress are associated with symptom expression in chronic fatigue syndrome Redox Rep. 5 584-9
[9]  
Morris G(2005)Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms Free RadicBiol Med. 39 953-959
[10]  
Anderson G(1994)The chronic fatigue syndrome: a comprehensive approach to its definition and study AnnIntern Med 121 1-17
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