Three new ent-kaurane diterpenes from the herbs of Wedelia prostrata

被引：0
作者：
Zhongnan Wu
Yubo Zhang
Li Yang
Nenghua Chen
Lin Jiang
Siqi Jiang
Guoqiang Li
Yaolan Li
Guocai Wang
机构：
[1] Jinan University,Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy
来源：
Journal of Natural Medicines | 2017年 / 71卷
关键词：
Asteraceae; -kaurane diterpenes; Cytotoxic activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Three new ent-kaurane diterpenes, 3α-angeloyloxy-17-hydroxy-ent-kaur-15-en-19-oic acid (1), 3α-tigloyloxy-17-hydroxy-ent-kaur-15-en-19-oic acid (2) and 3α-cinnamoyloxykaur-9(11),16-dien-19-oic acid (3), along with five known compounds (4-8), were isolated from the herbs of Wedelia prostrata (Asteraceae). The structures were determined by extensive analysis of their spectroscopic data (IR, UV, HRESIMS, 1D and 2D NMR). The isolated compounds were evaluated for their cytotoxic activity on human hepatocellular carcinoma HepG2 cells. Among them, all isolates exhibited cytotoxic activities with IC50 values ranging from 9.55 ± 0.45 to 53.92 ± 1.22 μM.
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页码：305 / 309
页数：4
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