Overrepresentation of HLA-DQ2 in Small Intestinal Neuroendocrine Tumor Patients

被引：2

作者：

Landerholm K. ^{[1
]}

Falkmer U. ^{[2
]}

Persson R. ^{[3
]}

Wall N. ^{[4
]}

Hallert C. ^{[5
]}

Järhult J. ^{[1
]}

机构：

[1] Department of Surgery, Ryhov County Hospital, Jönköping

[2] Department of Oncology, Ryhov County Hospital, Jönköping

[3] Department of Medicine, Kalmar County Hospital, Kalmar

[4] Department of Oncology, Linköping University Hospital, Linköping

[5] Coeliac Center, Norrköping Hospital, Norrköping

来源：

Journal of Gastrointestinal Cancer | 2014年 / 45卷 / 4期

关键词：

Carcinoid; Celiac disease; Gastro-enteropancreatic neuroendocrine tumor; HLA-DQ; Neuroendocrine tumor; Small intestinal neuroendocrine tumor;

D O I：

10.1007/s12029-014-9651-6

中图分类号：

学科分类号：

摘要：

Purpose: To investigate whether celiac disease risk haplotypes HLA-DQ2 and DQ8 also increase the risk for developing small intestinal neuroendocrine tumor (SI-NET).; Methods: Thirty-five patients with serotonin-producing jejunal and ileal SI-NET were examined with HLA-DQ genotyping and serology for IgA anti-tissue transglutaminase (tTG) antibodies.; Results: Twenty-one patients (60 %) carried HLA-DQ2 or DQ8, twice the frequency of the general population (P < 0.001). In particular DQ2 was overrepresented (P = 0.013). Gender, age, disease stage, histopathological grade, or multifocality of primary tumor did not differ between patients with DQ2 or DQ8 and patients with other HLA-DQ haplotypes. No patient in the study was diagnosed with celiac disease (latent or symptomatic) as anti-tTG antibodies were negative in all 35.; Conclusion: HLA-DQ haplotypes associated with celiac disease are overrepresented also in patients with SI-NET, in particular HLA-DQ2. © 2014, Springer Science+Business Media New York.

引用

页码：472 / 475

页数：3

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