Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal

被引：0
|
作者：
Mirko H.H. Schmidt
Frank Bicker
Iva Nikolic
Jeannette Meister
Tanja Babuke
Srdjan Picuric
Werner Müller-Esterl
Karl H. Plate
Ivan Dikic
机构：
[1] Institute of Biochemistry II,
[2] Johann Wolfgang Goethe University School of Medicine,undefined
[3] Institute of Neurology,undefined
[4] Johann Wolfgang Goethe University School of Medicine,undefined
来源：
Nature Cell Biology | 2009年 / 11卷
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摘要：
The secreted factor EGFL7, which is known to regulate cell migration and angiogenesis, is expressed in the brain where it binds receptors of the Notch family. Binding decreases Notch signalling, inhibits self-renewal of neural stem cells in culture and affects proliferation and differentiation of adult neural stem cells.
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页码：873 / 880
页数：7
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