Developmental and pathological angiogenesis in the central nervous system

被引：0
作者：
Mario Vallon
Junlei Chang
Haijing Zhang
Calvin J. Kuo
机构：
[1] Stanford University School of Medicine,Division of Hematology
来源：
Cellular and Molecular Life Sciences | 2014年 / 71卷
关键词：
Central nervous system; Angiogenesis; Brain tumors; Embryogenesis; Ischemic stroke;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Angiogenesis, the formation of new blood vessels from pre-existing vessels, in the central nervous system (CNS) is seen both as a normal physiological response as well as a pathological step in disease progression. Formation of the blood–brain barrier (BBB) is an essential step in physiological CNS angiogenesis. The BBB is regulated by a neurovascular unit (NVU) consisting of endothelial and perivascular cells as well as vascular astrocytes. The NVU plays a critical role in preventing entry of neurotoxic substances and regulation of blood flow in the CNS. In recent years, research on numerous acquired and hereditary disorders of the CNS has increasingly emphasized the role of angiogenesis in disease pathophysiology. Here, we discuss molecular mechanisms of CNS angiogenesis during embryogenesis as well as various pathological states including brain tumor formation, ischemic stroke, arteriovenous malformations, and neurodegenerative diseases.
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页码：3489 / 3506
页数：17
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  • [1] Shepro D(1993)Pericyte physiology FASEB J 7 1031-1038
  • [2] Morel NM(2010)Pericytes regulate the blood–brain barrier Nature 468 557-561
  • [3] Armulik A(2010)Pericytes are required for blood–brain barrier integrity during embryogenesis Nature 468 562-566
  • [4] Genove G(2006)Astrocyte-endothelial interactions at the blood–brain barrier Nat Rev Neurosci 7 41-53
  • [5] Mae M(2011)The role(s) of astrocytes and astrocyte activity in neurometabolism, neurovascular coupling, and the production of functional neuroimaging signals Eur J Neurosci 33 577-588
  • [6] Nisancioglu MH(2011)Lactate transport and metabolism in the human brain: implications for the astrocyte-neuron lactate shuttle hypothesis J Neurosci 31 4768-4770
  • [7] Wallgard E(2003)Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation Nat Neurosci 6 43-50
  • [8] Niaudet C(1997)Molecular mechanisms of vasculogenesis and embryonic angiogenesis J Cell Physiol 173 206-210
  • [9] He L(1971)Tumor angiogenesis: therapeutic implications N Engl J Med 285 1182-1186
  • [10] Norlin J(1972)Anti-angiogenesis: new concept for therapy of solid tumors Ann Surg 175 409-416
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