Synthesis and antiherpetic activity of (Z)- and (E)-9-(3-phosphonomethoxyprop-1-en-yl)adenines

被引：0
作者：
A. V. Ivanov
V. L. Andronova
G. A. Galegov
M. V. Jasko
机构：
[1] Russian Academy of Sciences,Engelhardt Institute of Molecular Biology
[2] Russian Academy of Medical Sciences,Ivanovskii Institute of Virology
来源：
Russian Journal of Bioorganic Chemistry | 2005年 / 31卷
关键词：
herpes simplex virus; nucleotides; phosphonates;
D O I：
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中图分类号：
学科分类号：
摘要：
The isomeric (Z)- and (E)-9-(3-phosphonomethoxyprop-1-en-yl)adenines were synthesized. The stereoselectivity of double bond formation was studied by variation of sulfonyl groups. The resulting phosphonates exhibited a moderate antiherpetic activity in a culture of Vero cells infected with herpes simplex type 1 virus. The Z-isomer was shown to be a more effective inhibitor of virus reproduction in the case of both wild and acyclovir-resistant strains.
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页码：58 / 65
页数：7
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