Preparation of a 99mTc-labeled graft polymer and its in vitro and in vivo evaluation

被引：0
作者：
Uğur Avcıbaşı
Taner Türkyarar
Ayşegül Karadağ
Buket Bakan
Nefise Ülkü Karabay Yavaşoğlu
Kevser Kuşat
Sinan Akgöl
Derya Gülcemal
Volkan Tekin
Fazilet Zümrüt Biber Müftüler
Gökcen Topal
Yasemin Parlak
Fikriye Gül Gümüşer
机构：
[1] Manisa Celal Bayar University,Department of Chemistry, Faculty of Art and Science
[2] Ege University,Department of Biology, Faculty of Science
[3] Department of Chemistry,Department of Biochemistry, Faculty of Science
[4] Faculty of Science,Department of Chemistry, Faculty of Science
[5] Dokuz Eylül University,Institute of Nuclear Sciences, Department of Nuclear Applications
[6] Ege University,Department of Nuclear Medicine, School of Medicine
[7] Ege University,Department of Molecular Biology and Genetics, Faculty of Science
[8] Ege University,undefined
[9] Manisa Celal Bayar University,undefined
[10] Atatürk University,undefined
来源：
Journal of Radioanalytical and Nuclear Chemistry | 2021年 / 329卷
关键词：
Nanopolymer; Graft Polymer; Cytotoxicity; Tc; Radiolabeling; Proline;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The aim of this study is the synthesis of a novel 99mTc-labeld graft polymer and the biological evaluation of its in vitro and in vivo properties. To this end, a L-proline-graft-poly(HEMA) was prepared and labeled with 99mTc. The radiochemical yield of approximately the 99mTc-labeled compound amounted to 97 ± 2.3%. The cytotoxicity test revealed no cytotoxic effect after a 24- and 48-h incubation. The results of the hemolysis test showed that hemolysis was non-toxic with an effect level of less than 2%. Subsequently, the biodistribution in healthy rats was determined. High accumulation of the polymer was observed in the pancreas, thyroid and prostate.
引用
收藏
页码：511 / 525
页数：14
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