Potential role of lipoxin in the management of COVID-19: a narrative review

被引：0
|
作者：
Gaber El-Saber Batiha
Ali I. Al-Gareeb
Engy Elekhnawy
Hayder M. Al-kuraishy
机构：
[1] Damanhour University,Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine
[2] Al-Mustansiriyah University,Department of Pharmacology, Toxicology and Medicine, College of Medicine
[3] Tanta University,Pharmaceutical Microbiology Department, Faculty of Pharmacy
来源：
Inflammopharmacology | 2022年 / 30卷
关键词：
Arachidonic acid; COVID-19; Inflammation; Lipoxins; SARS-CoV-2;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection leads to the development of coronavirus disease 2019 (COVID-19), which causes endothelial dysfunction (ED), oxidative stress (OS), and inflammatory disorders. These changes cause hypoxia and cytokine storm with the development of cardio-pulmonary complications. Bioactive lipids and other polyunsaturated fatty acids participate in a vital role in the SARS-CoV-2 infection process. One of these mediators is the anti-inflammatory compound, lipoxin (LX). LXs are produced from arachidonic acid (AA) by collaboration between 5-lipoxygenase (5-LO) and 12–15 LO during cell interactions. Thus, our goal was to review the probable role of LXs in COVID-19 regarding the effects of LXs on the inflammatory signaling pathways that are linked with COVID-19 pathogenesis and complications.
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页码：1993 / 2001
页数：8
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