Environmental Health and Long Non-coding RNAs

被引：82
作者：
Karlsson O. [1 ,2 ]
Baccarelli A.A. [2 ]
机构：
[1] Center for Molecular Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm
[2] Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, 02115, MA
来源：
Current Environmental Health Reports | 2016年 / 3卷 / 3期
关键词：
Chemicals; Disease; Epigenetics; LncRNA; Smoking; Toxicology;
D O I：
10.1007/s40572-016-0092-1
中图分类号：
学科分类号：
摘要：
An individual’s risk of developing a common disease typically depends on an interaction of genetic and environmental factors. Epigenetic research is uncovering novel ways through which environmental factors such as diet, air pollution, and chemical exposure can affect our genes. DNA methylation and histone modifications are the most commonly studied epigenetic mechanisms. The role of long non-coding RNAs (lncRNAs) in epigenetic processes has been more recently highlighted. LncRNAs are defined as transcribed RNA molecules greater than 200 nucleotides in length with little or no protein-coding capability. While few functional lncRNAs have been well characterized to date, they have been demonstrated to control gene regulation at every level, including transcriptional gene silencing via regulation of the chromatin structure and DNA methylation. This review aims to provide a general overview of lncRNA function with a focus on their role as key regulators of health and disease and as biomarkers of environmental exposure. © 2016, Springer International Publishing AG.
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页码：178 / 187
页数：9
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