Oral administration of probiotic bacteria (E. coli nissle,E. coli O83,Lactobacillus casei) influences the severity of dextran sodium sulfate-induced colitis in BALB/c mice

被引：0
作者：
A. Kokešová
L. Frolová
M. Kverka
D. Sokol
P. Rossmann
J. Bártová
H. Tlaskalová-Hogenová
机构：
[1] University Children Hospital Motol,Clinic of Pediatric Surgery
[2] Institute of Microbiology,Department of Immunology and Gnotobiology
[3] Academy of Sciences of the Czech Republic,Institute of Dental Research, 1st Medical Faculty
[4] Charles University and General Faculty Hospital,undefined
来源：
Folia Microbiologica | 2006年 / 51卷
关键词：
Lactobacillus; Mesalazine; Rectal Prolapse; Probiotic Bacterium; Probiotic Strain;
D O I：
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中图分类号：
学科分类号：
摘要：
Our study examined whether repeated preventive oral administration of live probiotic bacterial strainsEscherichia coli O83:K24:H31 (Ec O83),Escherichia coli Nissle 1917 O6:K5:H1 (Ec Nis) andLactobacillus casei DN 114001 (Lc) can protect mice against dextran sodium sulfate (DSS)-induced colitis. A significant decrease in average symptom score was observed in Ec O83-, Ec Nis- and Lc-pretreated group (p < 0.05). Significant differences in body mass loss between Lc pretreated mice with DSS-induced colitis were found when compared with nontreated mice (p < 0.05). PBS pretreated mice had a significantly shorter colon than Ec O83-, Ec Nis- and Lc-pretreated mice (p < 0.05). Administration of Lc significantly decreased the severity of DSS induced histological marks of inflammation (p < 0.05). A significant difference (p < 0.05) was also found in specific IgA level against given probiotic in enteral fluid between colitic mice and healthy mice pretreated with Ec O83 and Ec Nis.
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页码：478 / 484
页数：6
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