Maintenance N-acetyl cysteine treatment for bipolar disorder: A double-blind randomized placebo controlled trial

[1] Berk M(2011)Pathways underlying neuroprogression in bipolar disorder: focus on inflammation, oxidative stress and neurotrophic factors Neurosci Biobehav Rev 35 804-817

[2] Kapczinski F(2009)Is lithium in a class of its own? A brief profile of its clinical use Aust N Z J Psychiatry 43 1096-1104

[3] Andreazza AC(2007)The role of lamotrigine in the management of bipolar disorder Neuropsychiatr Dis Treat 3 463-474

[4] Dean OM(2005)N-Acetylcysteine ameliorates lithium-induced renal failure in rats Nephrol Dial Transplant 20 65-70

[5] Giorlando F(2011)Decreased levels of glutathione, the major brain antioxidant, in post-mortem prefrontal cortex from patients with psychiatric disorders Int J Neuropsychopharmacol 14 123-130

[6] Maes M(2009)Glutathione depletion in the brain disrupts short-term spatial memory in the Y-maze in rats and mice Behav Brain Res 198 258-262

[7] Yucel M(2011)N-acetyl cysteine restores brain glutathione loss in combined 2-cyclohexene-1-one and d-amphetamine-treated rats: relevance to schizophrenia and bipolar disorder Neurosci Lett 499 149-153

[8] Gama CS(2011)N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action J Psychiatry Neurosci 36 78-86

[9] Dodd S(2011)The efficacy of N-acetylcysteine as an adjunctive treatment in bipolar depression: an open label trial J Affect Disord 135 389-394

[10] Dean B(1995)Elevated platelet calcium mobilization and nitric oxide synthase activity may reflect abnormalities in schizophrenic brain Biochem Biophys Res Commun 212 375-380

[1] Berk M(2011)Pathways underlying neuroprogression in bipolar disorder: focus on inflammation, oxidative stress and neurotrophic factors Neurosci Biobehav Rev 35 804-817

[2] Kapczinski F(2009)Is lithium in a class of its own? A brief profile of its clinical use Aust N Z J Psychiatry 43 1096-1104

[3] Andreazza AC(2007)The role of lamotrigine in the management of bipolar disorder Neuropsychiatr Dis Treat 3 463-474

[4] Dean OM(2005)N-Acetylcysteine ameliorates lithium-induced renal failure in rats Nephrol Dial Transplant 20 65-70

[5] Giorlando F(2011)Decreased levels of glutathione, the major brain antioxidant, in post-mortem prefrontal cortex from patients with psychiatric disorders Int J Neuropsychopharmacol 14 123-130

[6] Maes M(2009)Glutathione depletion in the brain disrupts short-term spatial memory in the Y-maze in rats and mice Behav Brain Res 198 258-262

[7] Yucel M(2011)N-acetyl cysteine restores brain glutathione loss in combined 2-cyclohexene-1-one and d-amphetamine-treated rats: relevance to schizophrenia and bipolar disorder Neurosci Lett 499 149-153

[8] Gama CS(2011)N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action J Psychiatry Neurosci 36 78-86

[9] Dodd S(2011)The efficacy of N-acetylcysteine as an adjunctive treatment in bipolar depression: an open label trial J Affect Disord 135 389-394

[10] Dean B(1995)Elevated platelet calcium mobilization and nitric oxide synthase activity may reflect abnormalities in schizophrenic brain Biochem Biophys Res Commun 212 375-380