Non-IgE Medicated Food Allergy: Eosinophilic Esophagitis Update on the Pathogenesis, Clinical Features, and Management of Eosinophilic Esophagitis in Children

被引：0

作者：

Greenhawt M. ^{[1
]}

Aceves S.S. ^{[2
]}

机构：

[1] Division of Allergy and Clinical Immunology and the University of Michigan Food Allergy Center, University of Michigan Medical School, Ann Arbor, MI

[2] Division of Allergy, Immunology, Departments of Pediatrics and Medicine, University of California, San Diego, 9500 Gilman Drive, MC-0760, La Jolla, 92093-0760, CA

来源：

Current Pediatrics Reports | 2014年 / 2卷 / 2期

基金：

美国国家卫生研究院;

关键词：

Eosinophil; Eosinophilic esophagitis; Food allergy; Gastroesophageal reflux disease; Proton pump inhibitor; Remodeling; Topical corticosteroid;

D O I：

10.1007/s40124-014-0045-9

中图分类号：

学科分类号：

摘要：

Eosinophilic esophagitis (EoE) is a chronic allergic disorder of increasing worldwide prevalence. Diagnosis and management require upper gastrointestinal endoscopy with biopsy. Therapeutic strategies in children and adults include empiric and testing-based elimination diets as well as topical esophageal corticosteroids. The last 12 months have provided a number of insights including updated diagnostic/management guidelines, the role of PPI therapy, and an understanding that EoE disease mechanisms rely on basophils and mast cells in addition to eosinophils. Novel diagnostic techniques have been described and include the esophageal string test and a molecular gene array panel. In addition, new techniques for assessing esophageal rigidity have been reported. In this review, we summarize the most impactful findings in EoE over the last 12–15 months. © 2014, Springer Science + Business Media New York.

引用

页码：127 / 134

页数：7

共 60 条

[11]

Liacouras C.A., Wenner W.J., Brown K., Ruchelli E., Primary eosinophilic esophagitis in children: successful treatment with oral corticosteroids, J Pediatr Gastroenterol Nutr, 26, pp. 380-385, (1998)

[12]

Markowitz J.E., Spergel J.M., Ruchelli E., Liacouras C.A., Elemental diet is an effective treatment for eosinophilic esophagitis in children and adolescents, Am J Gastroenterol, 98, pp. 777-782, (2003)

[13]

Spergel J.M., Brown-Whitehorn T.F., Cianferoni A., (2012)

[14]

Kagalwalla A.F., Sentongo T.A., Ritz S., Et al., Effect of six-food elimination diet on clinical and histologic outcomes in eosinophilic esophagitis, Clin Gastroenterol Hepatol, 4, pp. 1097-1102, (2006)

[15]

Gonsalves N., Yang G.A., Doerfler B., Ritz S., Ditto A.M., Hirano I., Elimination diet effectively treats eosinophilic esophagitis in adults: food reintroduction identifies causative factors, Gastroenterology, 142, 1451-9, (2012)

[16]

Henderson C.J., Abonia J.P., King E.C., (2012)

[17]

Simon D., Marti H., Heer P., Simon H.U., Braathen L.R., Straumann A., Eosinophilic esophagitis is frequently associated with IgE-mediated allergic airway diseases, J Allergy Clin Immunol, 115, pp. 1090-1092, (2005)

[18]

Plaza-Martin A.M., Jimenez-Feijoo R., Andaluz C., Et al., Polysensitization to aeroallergens and food in eosinophilic esophagitis in a pediatric population, Allergol Immunopathol (Madr), 35, pp. 35-37, (2007)

[19]

Simon D., Straumann A., Dahinden C., Simon H.U., Frequent sensitization to Candida albicans and profilins in adult eosinophilic esophagitis, Allergy, 68, pp. 945-948, (2013)

[20]

Franciosi J.P., Hommel K.A., DeBrosse C.W., Et al., Quality of life in paediatric eosinophilic oesophagitis: what is important to patients?, Child Care Health Dev, 38, pp. 477-483, (2012)

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