Non-IgE Medicated Food Allergy: Eosinophilic Esophagitis Update on the Pathogenesis, Clinical Features, and Management of Eosinophilic Esophagitis in Children

被引：0

作者：

Greenhawt M. ^{[1
]}

Aceves S.S. ^{[2
]}

机构：

[1] Division of Allergy and Clinical Immunology and the University of Michigan Food Allergy Center, University of Michigan Medical School, Ann Arbor, MI

[2] Division of Allergy, Immunology, Departments of Pediatrics and Medicine, University of California, San Diego, 9500 Gilman Drive, MC-0760, La Jolla, 92093-0760, CA

来源：

Current Pediatrics Reports | 2014年 / 2卷 / 2期

基金：

美国国家卫生研究院;

关键词：

Eosinophil; Eosinophilic esophagitis; Food allergy; Gastroesophageal reflux disease; Proton pump inhibitor; Remodeling; Topical corticosteroid;

D O I：

10.1007/s40124-014-0045-9

中图分类号：

学科分类号：

摘要：

Eosinophilic esophagitis (EoE) is a chronic allergic disorder of increasing worldwide prevalence. Diagnosis and management require upper gastrointestinal endoscopy with biopsy. Therapeutic strategies in children and adults include empiric and testing-based elimination diets as well as topical esophageal corticosteroids. The last 12 months have provided a number of insights including updated diagnostic/management guidelines, the role of PPI therapy, and an understanding that EoE disease mechanisms rely on basophils and mast cells in addition to eosinophils. Novel diagnostic techniques have been described and include the esophageal string test and a molecular gene array panel. In addition, new techniques for assessing esophageal rigidity have been reported. In this review, we summarize the most impactful findings in EoE over the last 12–15 months. © 2014, Springer Science + Business Media New York.

引用

页码：127 / 134

页数：7

共 60 条

[1]

Dellon E.S., Gonsalves N., Hirano I., Furuta G.T., Liacouras C.A., (2013)

[2]

Liacouras C.A., Furuta G.T., Hirano I., Et al., Eosinophilic esophagitis: Updated consensus recommendations for children and adults, J Allergy Clin Immunol, 128, pp. 3-20, (2011)

[3]

Furuta G.T., Liacouras C.A., Collins M.H., Et al., Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment, Gastroenterology, 133, pp. 1342-1363, (2007)

[4]

Leslie C., Mews C., Charles A., Ravikumara M., Celiac disease and eosinophilic esophagitis: a true association, J Pediatr Gastroenterol Nutr, 50, pp. 397-399, (2010)

[5]

Greenhawt M., Aceves S.S., Spergel J.M., Rothenberg M.E., The management of eosinophilic esophagitis, J Allergy Clin Immunol, 1, (2013)

[6]

Dellon E.S., Jensen E.T., Martin C.F., Shaheen N.J., Kappelman M.D., This is a key study providing the first population-based estimates of the prevalence of EoE in the US in both children and adults, Clin Gastroenterol Hepatol, (2013)

[7]

van Rhijn B.D., Verheij J., Smout A.J., Bredenoord A.J., Rapidly increasing incidence of eosinophilic esophagitis in a large cohort, Neurogastroenterol Motil, 25, 47-52, (2013)

[8]

Noti M., Wojno E.D., Kim B.S., (2013)

[9]

Rothenberg M.E., Biology and treatment of eosinophilic esophagitis, Gastroenterology, 137, pp. 1238-1249, (2009)

[10]

Kelly K.J., Lazenby A.J., Rowe P.C., Yardley J.H., Perman J.A., Sampson H.A., Eosinophilic esophagitis attributed to gastroesophageal reflux: improvement with an amino acid-based formula, Gastroenterology, 109, pp. 1503-1512, (1995)

← 1 2 3 4 5 6 →