Mild hypothermia for neuroprotection after cardiac arrest

被引:0
作者
Kluge S. [1 ,2 ]
Kreymann G. [1 ]
机构
[1] Klinik für Intensivmedizin, Universitätsklinikum Hamburg-Eppendorf
[2] Medizinische Intensivstation, Klinik für Intensivmedizin, Universitätsklinikum Hamburg-Eppendorf, 20246 Hamburg
关键词
Cardiac arrest; Hypothermia; Neuroprotection; Resuscitation;
D O I
10.1007/s00063-006-1025-9
中图分类号
学科分类号
摘要
□ The favorable effect of hypothermia on brain damage resulting from cardiac arrest was first demonstrated in animal studies. Subsequent small-scale human studies have also shown positive effects. In 2002, two large randomized studies investigating the use of controlled mild hypothermia after resuscitation were published in the New England Journal of Medicine. The results convincingly showed a positive effect on survival and neurologic outcome. Based on the currently available data, the International Liaison Committee on Resuscitation (ILCOR) strongly recommends that unconscious adult patients who are resuscitated after ventricular fibrillation be cooled to temperatures between 32 and 34°C for 12-24 h. © Urban & Vogel.
引用
收藏
页码:203 / 207
页数:4
相关论文
共 24 条
[1]  
Bottiger B.W., Grabner C., Bauer H., Et al., Long term outcome after out-of-hospital cardiac arrest with physician staffed emergency medical services: The Utstein style applied to a midsized urban/suburban area, Heart, 82, pp. 674-679, (1999)
[2]  
Edgren E., Hedstrand U., Kelsey S., Et al., Assessment of neurological prognosis of comatose survivors of cardiac arrest, Lancet, 343, pp. 1055-1059, (1994)
[3]  
Randomized clinical study of thiopental loading in comatose survivors of cardiac arrest, N Engl J Med, 314, pp. 397-403, (1986)
[4]  
Jastremski M., Sutton-Tyrrell K., Vaagenes P., Et al., Glucocorticoid treatment does not improve neurological recovery following cardiac arrest, JAMA, 262, pp. 3427-3430, (1989)
[5]  
A randomized clinical study of a calcium-entry blocker (lidoflazine) in the treatment of comatose survivors of cardiac arrest, N Engl J Med, 324, pp. 1225-1231, (1991)
[6]  
Bernard S.A., Gray T.W., Buist M.D., Et al., Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia, N Engl J Med, 346, pp. 557-563, (2002)
[7]  
Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest, N Engl J Med, 346, pp. 549-556, (2002)
[8]  
Nolan J.P., Morley P.T., Vanden Hoek T.L., Et al., Therapeutic hypothermia after cardiac arrest: An advisory statement by the advanced life support task force of the International Liaison Committee on Resuscitation, Circulation, 108, pp. 118-121, (2003)
[9]  
Takino M., Okada Y., Hyperthermia following cardiopulmonary resuscitation, Intensive Care Med, 17, pp. 419-420, (1991)
[10]  
Sterz F., Safar P., Tisherman S., Et al., Mild hypothermic cardiopulmonary resuscitation improves outcome after prolonged cardiac arrest in dogs, Crit Care Med, 19, pp. 379-389, (1991)