The NF-κB/IL-6 pathway in metastatic androgen-independent prostate cancer: new therapeutic approaches?

被引：0
作者：
Bernard Paule
Stéphane Terry
Laurence Kheuang
Pascale Soyeux
Francis Vacherot
Alexandre de la Taille
机构：
[1] équipe Carcinogénèse et Pathologie Moléculaire des Tumeurs Urologiques,INSERM, Unité 841eq07, IMRB, Department of Immunology Dermatology Oncology
[2] Université Paris 12,Faculté de Médecine
[3] AP-HP,INSERM U841EQ07, Department of Urology
[4] Groupe Hospitalier Henri Mondor,undefined
[5] Service d’Urologie,undefined
[6] CHU Mondor,undefined
来源：
World Journal of Urology | 2007年 / 25卷
关键词：
Prostate cancer; NF-κB; IL-6; New therapies; Androgen independence; Metastasis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The nuclear factor of kappa beta (NF-κB) transcription factor regulates the transcription of numerous genes including that of interleukin 6 (IL-6). The IL-6 acts as an autocrine and paracrine growth factor of androgen-independent prostate cancer. An aberrant expression of the IL-6 gene and an increase in IL-6 expression are detected in bone metastatic and hormone-refractory prostate cancer. IL-6 has been suggested to have a crucial role in the resistance to chemotherapy or hormonal therapy involving apoptotic cell death. The NF-κB/IL-6 dependent pathways promote tumour-cell survival and in most situations protect cells against apoptotic stimuli. These data provide a rational framework for targeting NF-κB and IL-6 activity in novel biologically based therapies for aggressive and androgen independent prostate cancers.
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页码：477 / 489
页数：12
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