Overview of fungal terpene synthases and their regulation

被引：0
作者：
Ricardo A. González-Hernández
Norma A. Valdez-Cruz
Martha L. Macías-Rubalcava
Mauricio A. Trujillo-Roldán
机构：
[1] Instituto de Investigaciones Biomédicas,Departamento de Biología Molecular y Biotecnología
[2] Universidad Nacional Autónoma de México,Posgrado en Ciencias Biológicas
[3] Universidad Nacional Autónoma de México,Departamento de Productos Naturales, Instituto de Química
[4] Universidad Nacional Autónoma de México (UNAM),undefined
来源：
World Journal of Microbiology and Biotechnology | 2023年 / 39卷
关键词：
Terpenes; Synthases; Regulation; Fungal cultures; Isoprene; Mevalonate pathway;
D O I：
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摘要：
Terpenes and terpenoids are a group of isoprene-derived molecules that constitute the largest group of natural products and secondary metabolites produced by living things, with more than 25,000 compounds reported. These compounds are synthesized by enzymes called terpene synthases, which include several families of cyclases and enzymes. These are responsible for adding functional groups to cyclized structures. Fungal terpenoids are of great interest for their pharmacological properties; therefore, understanding the mechanisms that regulate their synthesis (regulation of the mevalonate pathway, regulation of gene expression, and availability of cofactors) is essential to direct their production. For this reason, this review addresses the detailed study of the biosynthesis of fungal terpenoids and their regulation by various physiological and environmental factors.
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