Cancer therapy using tumor-associated antigens to reduce side effects

被引：0
作者：
David Siu
机构：
[1] University of British Columbia,Department of Obstetrics and Gynaecology, British Columbia Research Institute for Children’s and Women’s Health
来源：
Clinical and Experimental Medicine | 2009年 / 9卷
关键词：
Tumor-associated antigens; Monoclonal antibodies; Immune response;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Tumor-associated antigens recently have become very popular in cancer therapy. They can be targeted to reduce side effects of traditional cancer therapy. In this review, ten promising tumor-associated antigens are being discussed in detail. The characteristics of each one are being reviewed in detail. Monoclonal antibodies attached to traditional anticancer agents can target a specific type of cancer cells thereby reducing the amount of traditional anticancer agents reaching normal tissues. This sort of cancer targeting can be a very attractive anticancer therapy because it substantially reduces the amount of side effects normally caused by traditional anticancer agents.
引用
收藏
页码：181 / 198
页数：17
相关论文
共 430 条
[1]  
Blakey DC(1992)Drug targeting with monoclonal antibodies. A review Acta Oncol 31 91-97
[2]  
Smith NL(1999)Immunohistochemically detecting target antigens in patient biopsies for tailoring monoclonal antibody based cancer therapy Hum Antibodies 9 61-65
[3]  
Finley JL(2002)Gemtuzumab ozogamicin, a potent and selective anti-CD33 antibody-calicheamicin conjugate for treatment of acute myeloid leukemia Bioconjug Chem 13 47-58
[4]  
Wennerberg AE(2004)Targeted therapy for malignant gliomas J Clin Neurosci 11 807-818
[5]  
Semer DA(2008)Tumor-specific antibody-mediated targeted delivery of Doxil reduces the manifestation of auricular erythema side effect in mice Int J Pharm 357 272-279
[6]  
Kearse KP(2006)Enhanced accumulation of long-circulating liposomes modified with the nucleosome-specific monoclonal antibody 2C5 in various tumours in mice: gamma-imaging studies Eur J Nucl Med Mol Imaging 33 1196-1205
[7]  
Hamann PR(2004)Tumor-targeted liposomes: doxorubicin-loaded long-circulating liposomes modified with anti-cancer antibody J Control Release 100 135-144
[8]  
Hinman LM(2003)Ovarian endometrioma associated with very high serum CA-125 levels Chang Gung Med J 26 695-699
[9]  
Hollander I(2003)Characterization of the oligosaccharides associated with the human ovarian tumor marker CA125 J Biol Chem 278 28619-28634
[10]  
Morokoff AP(2003)CA 125 levels in the preoperative assessment of advanced-stage uterine cancer Am J Obstet Gynecol 188 1195-1197
12345678910