Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury

被引：0
作者：
Li Yang
Tatiana Y Besschetnova
Craig R Brooks
Jagesh V Shah
Joseph V Bonventre
机构：
[1] Brigham and Women's Hospital,Renal Division, Department of Medicine
[2] Harvard Medical School,Renal Division, Department of Medicine
[3] Peking University First Hospital,Department of Systems Biology
[4] Harvard Medical School,Division of Health Sciences and Technology
[5] Harvard–Massachusetts Institute of Technology,undefined
来源：
Nature Medicine | 2010年 / 16卷
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摘要：
Inappropriate wound healing can lead to fibrosis of an organ and interference with its proper function. Joseph Bonventre and his colleagues have found that G2/M cell cycle arrest of tubular epithelial cells in the kidney after acute injury leads to fibrosis and that targeting this arrest, or the signaling that results from this arrest, is ameliorative for disease progression (pages 523–525 and 544–550).
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页码：535 / 543
页数：8
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