Gamma /delta T cells provide innate immunity against renal cell carcinoma

被引：0

作者：

Hirohito Kobayashi

Yoshimasa Tanaka

Junji Yagi

Hiroshi Toma

Takehiko Uchiyama

机构：

[1] Department of Urology,

[2] Tokyo Women's Medical University,undefined

[3] 8-1 Kawada-cho,undefined

[4] Shinjuku-ku,undefined

[5] Tokyo 162-8666,undefined

[6] Japan,undefined

[7] Department of Microbiology and Immunology,undefined

[8] Tokyo Women's Medical University,undefined

[9] 8-1 Kawada-cho,undefined

[10] Shinjuku-ku,undefined

[11] Tokyo 162-8666,undefined

[12] Japan e-mail: tuchi@research.twmu.ac.jp Tel.: +81-3-33538111; Fax: +81-3-52697411,undefined

来源：

Cancer Immunology, Immunotherapy | 2001年 / 50卷

关键词：

Key words Renal cell carcinoma; T cell; Immunotherapy; Flow cytometry; Vγ2 and Vδ2 junction sequences;

D O I：

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学科分类号：

摘要：

Host immune function plays a certain role against the development of renal cell carcinomas (RCCs), but the mechanism is not entirely understood. Human gamma/delta (γ/δ) T cells defend the body against infection. In this study, we clarify the role of γ/δ T cells in the surveillance system against RCCs by analyzing the γ/δ T cells in peripheral blood mononucleocytes (PBMs) and tumor infiltrating lymphocytes (TILs) from 41 patients with RCCs. The results showed that the number of γ/δ T cells expressing Vγ2 and Vδ2 in variable elements of TCR was elevated in the PBMs in 10 patients, but not in any of 32 healthy individuals. The proportion of patients with an elevated number of γ/δ T cells (>10%) increased with cancer stage. The level of the γ/δ T cells decreased after surgery. The γ/δ T cells in the TILs were more activated than those in the PBMs. Evaluation of the junctional diversity of TCR Vγ2 and Vδ2 chains showed that the increased peripheral blood γ/δ T cells were oligoclonal rather than polyclonal. Taken together, our findings suggest that γ/δ T cells recognize certain RCC-related antigens and play a role in the surveillance system against RCCs.

引用

页码：115 / 124

页数：9