Cadherin adhesion controlled by cortical actin dynamics

被引:0
|
作者
Johan de Rooij
机构
[1] Johan de Rooij is in Molecular Cancer Research,
[2] Center for Molecular Medicine,undefined
[3] University Medical Center Utrecht,undefined
[4] 3584 CG,undefined
[5] Utrecht,undefined
[6] The Netherlands,undefined
来源
Nature Cell Biology | 2014年 / 16卷
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摘要
Cadherin-containing cell–cell junctions respond to intercellular tension by increasing their size, strength and complexity. The mechanical regulation of cadherin adhesions is now shown to involve myosin-dependent tension in the cortical actomyosin cytoskeleton. This reduces actin turnover to decrease the mobility of cadherin molecules and increase their concentration at junctions.
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页码:508 / 510
页数:2
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