Discordant lymphoma consisting of splenic mantle cell lymphoma and marginal zone lymphoma involving the bone marrow and peripheral blood: A case report

被引：5

作者：

Carulli G. ^{[1
]}

Marini A. ^{[2
]}

Ciancia E.M. ^{[3
]}

Bruno J. ^{[4
]}

Vignati S. ^{[3
]}

Lambelet P. ^{[5
]}

Cannizzo E. ^{[1
]}

Ottaviano V. ^{[1
]}

Galimberti S. ^{[1
]}

Caracciolo F. ^{[1
]}

Ferreri M.I. ^{[6
]}

Ciabatti E. ^{[1
]}

Petrini M. ^{[1
]}

机构：

[1] Department of Oncology, Transplants and New Technologies in Medicine, Division of Hematology and Section of Flow Cytometry, University of Pisa, Pisa

[2] Laboratory of Clinical Pathology, Versilia Hospital, Lido di Camaiore

[3] Division of Pathology 2, AOUP, Pisa

[4] Division of Pathology, Versilia Hospital, Lido di Camaiore

[5] Division of Medicine, Versilia Hospital, Lido di Camaiore

[6] Laboratory of Cytogenetics, AOUP, Santa Chiara Hospital

来源：

Journal of Medical Case Reports | / 5卷 / 1期

关键词：

Lymphoma; Mantle Cell Lymphoma; Marginal Zone Lymphoma; Bone Marrow Infiltration; Splenic Marginal Zone Lymphoma;

D O I：

10.1186/1752-1947-5-476

中图分类号：

学科分类号：

摘要：

Introduction. Discordant lymphomas are rare entities characterized by the simultaneous presence of two distinct types of lymphomas in different anatomic sites. We describe a very rare case of simultaneous occurrence of splenic mantle cell lymphoma and marginal zone lymphoma involving the bone marrow and peripheral blood. Case presentation. We report the case of a 60-year-old asymptomatic Caucasian woman in whom discordant lymphomas were discovered when a slight lymphocytosis and a conspicuous splenomegaly were observed. The different morphological, immunophenotypical and immunohistochemical features found in the different pathologic samples obtained from peripheral blood, bone marrow and spleen sections made it possible to differentiate two types of non-Hodgkin B-cell lymphomas: a mantle cell lymphoma infiltrating the spleen and a marginal zone lymphoma involving both the bone marrow and peripheral blood. Since a similar IgH gene rearrangement was found both in the bone marrow and in the spleen, the hypothesis of a common origin, followed by a different clonal selection of the neoplastic lymphocytes may be taken into consideration. Conclusion: Our case emphasizes the usefulness of investigating simultaneous specimens from different anatomic sites from the same patient and the relevant diagnostic role of splenectomy. © 2011Carulli et al; licensee BioMed Central Ltd.

引用

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