Eucalyptus oil reduces allergic reactions and suppresses mast cell degranulation by downregulating IgE-FcεRI signalling

被引：0
作者：
Tomoya Nakamura
Naoki Yoshida
Yu Yamanoi
Akira Honryo
Hiroyuki Tomita
Hiroki Kuwabara
Yoshihiko Kojima
机构：
[1] Ikeda Mohando Co.,Department of R&D Center
[2] Ltd,undefined
来源：
Scientific Reports | / 10卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Eucalyptus oil has been used since ancient times for its bactericidal, anti-inflammatory, analgesic and sedative effects. In recent years, the action of Eucalyptus oil has been scientifically proven, and there have been reports that Eucalyptus oil suppresses the production of chemokines, cytokines and lipid mediators in basophils, alveolar macrophages and monocytes. Based on this information, we aimed to verify whether Eucalyptus oil can be used for allergic dermatitis, the incidence of which has been increasing among human skin diseases. This effect was verified using a mouse IgE-mediated local allergic model. In conclusion, topical application of Eucalyptus oil suppressed oedema and vascular permeability enhancement due to IgE-mediated allergic on the skin. In addition, we also verified the degranuration of mast cells, which is a part of its action, and examined whether 1,8-cineole, which is the main component of Eucalyptus oil, suppresses the phosphorylation of PLCγ and p38 directly or indirectly. 1,8-cineole was found to suppress degranulation of mast cells.
引用
收藏
相关论文
共 102 条
  • [11] Kehrl W(2015)Eucalyptol suppresses matrix metalloproteinase-9 expression through an extracellular signal-regulated kinase-dependent nuclear factor-kappa B pathway to exert anti-inflammatory effects in an acute lung inflammation model J. Pharm. Pharmacol. 67 1066-412
  • [12] Sonnemann U(2009)Anti-inflammatory effects of Myrtol standardized and other essential oils on alveolar macrophages from patients with chronic obstructive pulmonary disease Eur. J. Med. Res. 14 205-510
  • [13] Dethlefsen U(1998)Antiinflammatory effects of euclyptol (1.8-cineole) in bronchial asthma: Inhibition of arachidonic acid metabolism in human blood monocytes ex vivo Eur. J. Med. Res. 3 407-879
  • [14] Juergens UR(1998)Inhibition of cytokine production and arachidonic acid metabolism by eucalyptol (1.8-cineole) in human blood monocytes in vitro Eur. J. Med. Res. 3 508-1134
  • [15] Meister R(2017)Transient receptor potential cation channel subfamily M member 8 channels mediate the anti-inflammatory effects of eucalyptol Br. J. Pharmacol. 174 867-244
  • [16] Wittig T(2013)Phytochemical composition of Cymbopogon citratus and Eucalyptus citriodora essential oils and their anti-inflammatory and analgesic properties on Wistar rats Mol. Biol. Rep. 40 1127-519
  • [17] Beuscher N(2000)Antiinflammatory and antinociceptive effects of 1,8-cineole a terpenoid oxide present in many plant essential oils Phytother. Res. 14 240-3234
  • [18] de Mey C(1999)The examination of the usefulness for atopic dermatitis patient of Eucalyptus extract mixture bathing medicine Nishinihon J. Dermatol. 61 515-1419
  • [19] Ikawati Z(2016)The novel H2 S donor 4-carboxy-phenyl isothiocyanate inhibits mast cell degranulation and renin release by decreasing intracellular calcium Br. J. Pharmacol. 173 3222-786
  • [20] Wahyuono S(2014)DOCK5 functions as a key signaling adaptor that links FcepsilonRI signals to microtubule dynamics during mast cell degranulation J. Exp. Med. 211 1407-515
12345678910