Influence of vitreous factors after vitrectomy for macular edema in patients with central retinal vein occlusion

被引：6

作者：

Noma H. ^{[1
]}

Funatsu H. ^{[1
]}

Mimura T. ^{[2
]}

Eguchi S. ^{[3
]}

Shimada K. ^{[4
]}

机构：

[1] Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women's Medical University, Yachiyo, Chiba 276-8524, 477-96, Owada-shinden

[2] Department of Ophthalmology, University of Tokyo, Graduate School of Medicine, Tokyo

[3] Department of Ophthalmology, Eguchi Eye Hospital, Hakodate

[4] Department of Hygiene and Public Health II, Tokyo Women's Medical University, Tokyo

来源：

International Ophthalmology | 2011年 / 31卷 / 5期

基金：

日本学术振兴会;

关键词：

Central retinal vein occlusion; Macular edema; Pigment epithelium-derived factor; Soluble intercellular adhesion molecule 1; Vascular endothelial growth factor; Visual prognosis;

D O I：

10.1007/s10792-011-9480-6

中图分类号：

学科分类号：

摘要：

To investigate whether vitreous fluid levels of vascular endothelial growth factor (VEGF), pigment epithelium-derived factor (PEDF), and soluble intercellular adhesion molecule 1 (sICAM-1) influence visual prognosis and macular edema in patients with central retinal vein occlusion (CRVO). A prospective observational study was performed in 31 consecutive CRVO patients (31 eyes) with macular edema who underwent vitrectomy. Best-corrected visual acuity (BCVA), retinal thickness (examined by OCT), and vitreous fluid levels of VEGF, PEDF, and sICAM-1 were determined. Patients were followed for at least 6 months after surgery. Both visual acuity and retinal thickness showed significant improvement at 6 months postoperatively (P = 0.012 and P < 0.001, respectively). Vitreous fluid levels of VEGF were significantly higher (P = 0.027) in patients who showed less improvement of BCVA after vitrectomy than in those with a better outcome. Conversely, vitreous levels of PEDF were significantly lower (P = 0.047) in patients with less improvement of BCVA than in those with a better outcome. Vitreous levels of sICAM-1 were not significantly correlated with BCVA after vitrectomy (P = 0.731). Multiple regression analysis demonstrated that vitreous fluid levels of VEGF and PEDF were significant determinants of the improvement of BCVA (P = 0.013 and P = 0.007, respectively). These results suggest that vitreous fluid levels of VEGF and PEDF might influence visual prognosis after vitrectomy in CRVO patients with macular edema. © 2011 Springer Science+Business Media B.V.

引用

页码：393 / 402

页数：9

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