Vascular endothelial growth factor expression in rat skin incision wound

被引：0
作者：
Makoto Nogami
Tomoaki Hoshi
Mayumi Kinoshita
Tomomi Arai
Michiho Takama
Ichiro Takahashi
机构：
[1] Teikyo University School of Medicine,Department of Legal Medicine
[2] Teikyo University School of Medicine,Central Laboratory for Electron Microscopy
来源：
Medical Molecular Morphology | 2007年 / 40卷
关键词：
Vascular endothelial growth factor; Skin; Wound; Immunohistochemistry; mRNA;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Vascular endothelial growth factor (VEGF) is a glycoprotein that enhances vascular permeability, induces chemotaxis and activation of monocytes/macrophages, and promotes growth of vascular endothelial cells. We report that infiltrating polymorphonuclear leukocytes in an incision wound in rat skin express VEGF from 1 day after the injury, as shown by immunohistochemistry. VEGF is also present in macrophages, fibroblast-like cells, and endothelial cells 3 and 7 days after the injury. mRNA for VEGF is statistically significantly increased in the wound area in the tissue 1 day after the skin incision compared with 3 and 7 days after the incision. The VEGF protein content in the wound tissue is statistically significantly higher in the wound than in control skin at 1 and 3 days after skin incision. Our results indicate that VEGF is produced by inflammatory cells to induce vascularization in the early stage of the wound healing process.
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页码：82 / 87
页数：5
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