Recent advances in target identification by natural product based chemical probes

被引：0
作者：
Benke Hong
Ting Dong
Xiaoguang Lei
机构：
[1] Peking University,Beijing National Laboratory for Molecular Sciences, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center, and Peking
[2] Tianjin University,Tsinghua Center for Life Sciences
[3] National Institute of Biological Sciences,School of Pharmaceutical Science and Technology
[4] Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences,undefined
来源：
Science China Chemistry | 2016年 / 59卷
关键词：
natural product; chemical probe; chemical biology; target ID;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Natural products have been extensively used to treat diseases throughout human history. These are mainly because natural products normally target biological macromolecules selectively. Target identification could help us to develop new therapeutic agents and discover new biological pathways underlying human diseases. Herein, we highlight some recent examples of using natural products and their derivatives as chemical probes to identify the molecular targets and elucidate mode of action.
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页码：1088 / 1092
页数：4
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