F-19848 A, a Novel Inhibitor of Hyaluronic Acid Binding to Cellular Receptor CD44

被引：0
|
作者：
Yuki Hirota-Takahata
Hosami Harada
Isshin Tanaka
Tomoko Nakata
Mutsuo Nakajima
Masaaki Takahashi
机构：
[1] Exploratory Research Laboratories II,
[2] Daiichi-Sankyo Co.,undefined
[3] Ltd.,undefined
[4] Advanced Technology Research Laboratories,undefined
[5] Daiichi-Sankyo Co.,undefined
[6] Ltd.,undefined
来源：
The Journal of Antibiotics | 2007年 / 60卷
关键词：
F-19848 A; hyaluronic acid; CD44; inhibitor;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In the course of our screening for inhibitors of hyaluronic acid (HA) binding to cellular receptor CD44, a novel inhibitor, F-19848 A, was isolated from the cultured broth of the fungus strain Dacrymyces sp. SANK 20204. This compound inhibited the binding of CD44 and HA with an IC50 value of 23.5 μM and CD44-dependent HA degradation was inhibited with an IC50 value of 98.6 μM in a cell-based assay. The structure was elucidated by physico-chemical properties, analysis of spectral data, and decomposition experiments.
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页码：633 / 639
页数：6
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