A novel regulator in cancer initiation and progression: long noncoding RNA SHNG9

被引：0
作者：
Mingxing Zhao
Yang Zhang
Shen Shen
机构：
[1] The First Affiliated Hospital of Zhengzhou University,Department of Traditional Chinese Medicine
[2] The First Affiliated Hospital of Zhengzhou University,Department of Geriatric Respiratory and Sleep
[3] The First Affiliated Hospital of Zhengzhou University,Department of Infectious Diseases
来源：
Clinical and Translational Oncology | 2023年 / 25卷
关键词：
SNHG9; lncRNA; Cancer; ceRNA; Diagnosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Cancer has become the most common life-threatening disease in the world. Cancers presenting with advanced stages and metastasis show poor prognosis, even with the application of radiotherapy, surgery, chemotherapy and immunotherapy. It is of great importance to explore novel, efficient biomarkers and their internal mechanisms. Recently, it has been reported that long noncoding RNAs (lncRNAs) play important roles in tumor initiation and progression, influencing downstream mRNAs by interacting with miRNAs and functioning as sponges in competing endogenous RNA (ceRNA) networks. Small nucleolar RNA host gene 9 (SNHG9) binds with miRNAs, inducing miRNA downregulation. The downregulated miRNAs enhance downstream target gene expression via ceRNA networks. Dysregulation of SNHG9 is widely observed in tumors and is associated with clinical prognosis features, which makes it a valuable target for cancer biomarkers and therapeutics. Dysregulated SNHG9 in tumor cells also functions in tumor proliferation, colony formation, migration, invasion and inhibition of apoptosis and tumor cell metabolism. This systematic review of SNHG9 in tumors provides new perspectives on cancer diagnosis and treatment.
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页码：1512 / 1521
页数：9
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