Differential Regulation by Mechanical Stretch of the Expressions of Large-Conductance Ca2+-Activated K+ Channel and L-Type Voltage-Dependent Ca2+ Channel in Rat Uterine Smooth Muscle Cells

被引：0
作者：
Xiaoling Jia
Chao Gao
Xia Wang
Lin-Hua Jiang
Yubo Fan
机构：
[1] Beihang University,Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering
[2] University of Leeds,School of Biomedical Sciences, Faculty of Biological Sciences
[3] Xinxiang Medical University,Department of Physiology and Pathophysiology and Sino
[4] Beihang University,UK Joint Laboratory of Brain Function and Injury of Henan Province
来源：
The Journal of Membrane Biology | 2022年 / 255卷
关键词：
BK; channel; L-VDCC; Stretch; Uterine smooth muscle cell;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Large-conductance Ca2+-activated K+ (BKCa) channel and L-type voltage-dependent Ca2+ channel (L-VDCC) play important roles in regulating uterine contractility. The uterus stretch, occurring during pregnancy, is a critical factor to trigger uterine contraction. However, how mechanical stimuli impact the two channels remains unknown. Here we investigated the effects of exposure to mechanical stretches with varying magnitudes and durations on expressions of the two channels in rat uterine smooth muscle cells. Our results show that stretch down-regulates the BKCa channel expression but upregulates the L-VDCC expression. These findings are helpful to better understand the roles of L-VDCC and BKCa channel in stretch-triggered uterine contraction.
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页码：357 / 361
页数：4
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