Effects of Atrial Natriuretic Peptide on DNA Synthesis and NADPH Diaphorase Activity in Epitheliocytes and Smooth Muscle Cells of the Respiratory Tract in Newborn Albino Rats

被引：0
作者：
O. A. Lebed'ko
S. S. Timoshin
V. I. Tsygankov
机构：
[1] Far-Eastern State Medical University,Institute of Maternity and Child Welfare, Khabarovsk Branch, Far
来源：
Bulletin of Experimental Biology and Medicine | 2002年 / 133卷
关键词：
atrial natriuretic peptide; DNA synthesis; nitric oxide; epithelium; smooth muscle cells; respiratory tract6;
D O I：
暂无
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学科分类号：
摘要：
Newborn rats received single intraperitoneal injections of atrial natriuretic peptide (1-28) in a dose of 3.2×10-8 mol/kg on day 6 of life. Autoradiography with 3H-thymidine showed that the peptide inhibited DNA synthesis in smooth muscle cells of the respiratory tract. Pretreatment with nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester attenuated, but did not abolish the effect of atrial natriuretic peptide (1-28). Histochemical assay for NADPH diaphorase showed that nitric oxide constitutively produced in the epithelium is involved in the growth-inhibitory effect of atrial natriuretic peptide (1-28) on proliferating smooth muscle cells.
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页码：26 / 29
页数：3
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