SOX11 is a biomarker for cyclin D1-negative mantle cell lymphoma

被引：24

作者：

Narurkar R. ^{[1
]}

Alkayem M. ^{[1
]}

Liu D. ^{[1
]}

机构：

[1] Department of Medicine, Westchester Medical Center and New York Medical College, Valhalla, 10595, NY

来源：

Biomarker Research | / 4卷 / 1期

关键词：

Mantle Cell Lymphoma; SOX11 Expression; Hairy Cell Leukemia; SOX11 Protein; Small Lymphocytic Lymphoma;

D O I：

10.1186/s40364-016-0060-9

中图分类号：

学科分类号：

摘要：

Cyclin D1 (CCND1) protein overexpression and/or the t(11;14)(q13;q32) translocation are the pathognomonic hallmarks of mantle cell lymphoma (MCL). However, there have been cases that lacked both t(11;14) and cyclin D1 protein but still had a gene expression profile suggesting a diagnosis of MCL. SOX11 expression was detected in most cyclin D1-negative MCL and can serve as a specific biomarker for the diagnosis of this subset of MCL. Lack of SOX11 expression in MCL was associated with an indolent subset and favorable prognosis. © 2016 Narurkar et al.

引用

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