Bioactivity-Directed Fractionation of Alkaloids from Some Amaryllidaceae Plants and Their Anticholinesterase Activity

被引：0
作者：
I. Orhan
B. Sener
机构：
[1] Gazi University,Department of Pharmacognosy, Faculty of Pharmacy
来源：
Chemistry of Natural Compounds | 2003年 / 39卷
关键词：
Alzheimer's disease; Amaryllidaceae; Ellman method; galanthamine;
D O I：
暂无
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学科分类号：
摘要：
Chloroform:methanol extracts of the bulbs of five Amaryllidaceae plants, namely Galanthus elwesii Hooker fil., G. Ikariae L., Narcissus tazetta subsp. tazetta L., Leucojum aestivum L., and Pancratium maritimum L. growing in Turkey, were evaluated for their anticholinesterase activity by the Ellman method in comparison with galanthamine as the standard drug. Bioactivity-directed fractionation and isolation studies carried out on G. ikariae and N. tazetta subsp. tazetta extracts afforded eight Amaryllidaceae-type alkaloids in total. We found that the activity of both plant extracts was due to the synergistic interaction of the alkaloids isolated.
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页码：383 / 386
页数：3
相关论文
共 95 条
[1]  
Adams R. L.(1984)undefined Neurolog. Clin. 4 387-undefined
[2]  
Craig P. L.(1997)undefined Neurology 48 35-undefined
[3]  
Parsons O. A.(1993)undefined Med. Clin. Nort. Am. 77 215-undefined
[4]  
Aisen P. S.(1992)undefined Neurology 42 115-undefined
[5]  
Davis K. L.(1999)undefined J. Neurol. Neurosurg. Psychiatry 66 137-undefined
[6]  
Arnold S. E.(1965)undefined Exp. Neurol. 24 477-undefined
[7]  
Kumar A.(1978)undefined Neuropath. Appl. Neurobiol. 4 273-undefined
[8]  
Bachman D. L.(2001)undefined Clin. Geriatr. Med. 17 337-undefined
[9]  
Wolf P. A.(2001)undefined Rev. Neurol. 32 172-undefined
[10]  
Linn R. T.(2001)undefined Prog. Neuropsychoph. 25 73-undefined
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