Repair of radiation damage to DNA

被引：0
作者：
H Willers
J Dahm-Daphi
S N Powell
机构：
[1] Massachusetts General Hospital and Harvard Medical School,Department of Radiation Oncology
[2] University Hospital Hamburg-Eppendorf,Department of Radiotherapy and Radiooncology
[3] Martinistrasse 52,undefined
来源：
British Journal of Cancer | 2004年 / 90卷
关键词：
ionising radiation; DNA double-strand breaks; repair; recombination; replication;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
DNA double-strand breaks constitute the most dangerous type of DNA damage induced by ionising radiation (IR). Accordingly, the resistance of cells to IR is modulated by three intimately related cellular processes: DNA repair, recombination, and replication. Significant discoveries in this field of research have been made over the last few years. A picture seems to be emerging in which perturbations of recombination in cancer cells are a more widespread cause of genomic instability than previously appreciated. Conversely, such cells may also be more sensitive to certain chemotherapeutic drugs and to IR. Thus, the alterations in recombination that promote carcinogenesis by causing genomic instability may also be the weakness of the tumours that arise in this setting, a concept which could hold great promise for the advancement of cancer treatment in the not too distant future.
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页码：1297 / 1301
页数：4
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