High risk human papillomavirus and Epstein Barr virus in human breast milk

被引：33

作者：

Wendy K Glenn

Noel J Whitaker

James S Lawson

机构：

[1] School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney

来源：

BMC Research Notes | / 5卷 / 1期

关键词：

Epstein barr virus; Human milk; Human papillomavirus;

D O I：

10.1186/1756-0500-5-477

中图分类号：

学科分类号：

摘要：

Background: Multiple viruses, including human immunodeficiency virus, Epstein Barr virus (EBV) and mouse mammary tumour virus have been identified in human milk. High risk human papillomavirus (HPV) sequences have been identified in breast cancer. The aim of this study is to determine if viral sequences are present in human milk from normal lactating women. Findings. Standard (liquid) and in situ polymerase chain reaction (PCR) techniques were used to identify HPV and EBV in human milk samples from normal lactating Australian women who had no history of breast cancer.High risk human papillomavirus was identified in milk samples of 6 of 40 (15%) from normal lactating women - sequencing on four samples showed three were HPV 16 and one was HPV 18. Epstein Barr virus was identified in fourteen samples (33%). Conclusion: The presence of high risk HPV and EBV in human milk suggests the possibility of milk transmission of these viruses. However, given the rarity of viral associated malignancies in young people, it is possible but unlikely, that such transmission is associated with breast or other cancers. © 2012 Glenn et al.; licensee BioMed Central Ltd.

引用

共 17 条

[1]

Kjaer S.K., Chackerian B., Van Den Brule A.J., Svare E.I., Paull G., Walbomers J.M., Schiller J.T., Bock J.E., Sherman M.E., Lowy D.R., Meijer C.L., High-risk human papillomavirus is sexually transmitted

[2]

evidence from a follow-up study of virgins starting sexual activity (intercourse), Cancer Epidemiol Biomarkers Prev, 10, pp. 101-116, (2001)

[3]

Chen A.C., Keleher A., Kedda M.A., Spurdle A.B., McMillan N.A., Antonsson A., Human papillomavirus: DNA detected in peripheral blood samples from healthy Australian male blood donors, J Med Virol, 81, pp. 1792-1796, (2009)

[4]

Rautava J., Syrjanen S., Human papillomavirus infections in the oral mucosa, J Am Dent Assoc, 142, pp. 905-914, (2011)

[5]

Syrjanen S., Current concepts on human papillomavirus infections in children, APMIS, 118, pp. 494-509, (2010)

[6]

Sarkola M., Funtala M., Grenman S., Syganen S., Human papillomavirus DNA detected in breast milk, Ped Inf Dis J, 27, pp. 557-558, (2008)

[7]

Cazzaniga M., Gheit T., Casadio C., Kahn N., MacIs D., Valenti F., Miller M.J., Sylla B.S., Akiba S., Bonnani B., Decensi A., Veronesi V., Tommasino M., Analysis of the presence of cutaneous and mucosal papilloma virus types in ductal lavage fluid, milk, and colostrum to evaluate its role in breast carcinogenesis, Breast Cancer Res Treat, 114, pp. 599-605, (2009)

[8]

Mammas I.N., Zaravinos A., Sourvinos G., Myriokefalitakis N., Theodoridou M., Spandidos D.A., Can 'high-risk' human papillomaviruses (HPVs) be detected in human breast milk?, Acta Paediatr, 100, pp. 705-707, (2011)

[9]

Hagensee M.E., Herrel N., Dangelo A., Sutton K., Clark R., Cameron J.E., Epstein Barr Virus Interacts with Human Papilloma Virus to Decrease Apoptosis in Vitro and Increase Cervical Dysplasia in Vivo, (2011)

[10]

Glenn W.K., Heng B., Whitaker N.J., Lawson J.S., Letter to the Editor Reply: Koilocytes indicate a role for human papilloma virus in breast milk, Br J Cancer, 102, pp. 788-788, (2010)

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