Primary gastric choriocarcinoma: Two case reports and a pooled analysis of 53 cases

被引：46

作者：

Kobayashi A. ^{[1
,3
]}

Hasebe T. ^{[1
]}

Endo Y. ^{[1
]}

Sasaki S. ^{[2
]}

Konishi M. ^{[3
]}

Sugito M. ^{[3
]}

Kinoshita T. ^{[3
]}

Saito N. ^{[3
]}

Ochiai A. ^{[1
]}

机构：

[1] Pathology Division, National Cancer Center Research Institute East, Kashiwa, Chiba 277-8577

[2] Epidemiology and Biostatistics Division, National Cancer Center Research Institute East, Kashiwa

[3] Department of Surgery, National Cancer Center Hospital East, Kashiwanoha, Kashiwa

来源：

Gastric Cancer | 2005年 / 8卷 / 3期

关键词：

Choriocarcinoma; Prognosis; Stomach;

D O I：

10.1007/s10120-005-0332-9

中图分类号：

学科分类号：

摘要：

Primary gastric choriocarcinoma (PGC) is a rare tumor. In total, approximately 140 cases of PGC have been reported in the international medical literature. However, the clinical behavior, tumor characteristics, and prognostic parameters of PGC have not been clearly described. We conducted a pooled analysis to clarify the tumor characteristics and prognostic parameters in 53 patients with PGCs, including 2 patients treated at our hospital. The following variables were examined as potential prognostic factors: (1) sex, (2) age, (3) depth of invasion, (4) size, (5) histology, (6) nodal metastasis, (7) distant lymph node metastasis, (8) synchronous liver metastasis, (9) residual tumor, and (10) chemotherapy (not given or given). Univariate and multivariate analyses showed that the presence of residual tumor and synchronous liver metastasis and the absence of chemotherapy were significantly associated with an increased hazard rate (HR) of short overall survival (OS). Pooled analysis, including the two patients with PGC treated at our facility, demonstrated that the presence of a curative operation and chemotherapy, and the absence of synchronous liver metastasis were the strongest indicators of a favorable clinical course in patients with PGC. © 2005 by International and Japanese Gastric Cancer Associations.

引用

页码：178 / 185

页数：7

共 37 条

[11]

Maruyama M., Kudo T., Kuwahara H., Takamatsu T., Sugano N., Ebuchi M., A case of gastric cancer containing choriocarcinoma and yolk sac tumor (in Japanese), Nippon Shokaki Shudan Kenshin (J Gastroenterol Mass Survery), 35, (1997)

[12]

Kaneko T., Mochizuki M., Hakozaki H., Igari S., Imprint cytology of primary gastric choriocarcinoma. a case report (in Japanese with English abstract), J Jpn Soc Clin Cytol, 36, pp. 531-6, (1997)

[13]

Sato K., Watanabe O., Anzai K., Sano Z., Hiroishi K., Nakayama K., Primary choriocarcinoma of the stomach (in Japanese with English abstract), Shokaki Naishikyo (Endoscopia Digestiva), 7, pp. 1289-96, (1995)

[14]

Tamada H., A case of primary gastric choriocarcinoma (in Japanese), Jpn J Gastroenterol Surg, 30, (1997)

[15]

Ushida T., Morozumi K., Shibata S., Ikeda Y., A case of primary gastric choriocarcinoma (in Japanese), Jpn J Gastroenterol Surg, 30, (1997)

[16]

Inomata Y., Tadaoka N., Yoshinaga K., Two cases of primary gastric choriocarcinoma and squamous cell carcinoma of the stomach (in Japanese), Nippon Shokaki Shudan Kenshin (J Gastroenterol Mass Survery), 35, (1997)

[17]

Jan Y.J., Chen J.T., Ho W.L., Wu C.C., Yeh D.C., Primary coexistent adenocarcinoma and choriocarcinoma of the stomach. a case report and review of the literature, J Clin Gastroenterol, 25, pp. 550-4, (1997)

[18]

Uda M., Sakaue K., Nakao A., Mitsuoka S., A case of primary gastric choriocarcinoma (in Japanese). Niseki Igaku, Jpn Red Cross Med J, 48, (1996)

[19]

Kinoshita H., Sasaki M., Onishi H., Nishino E., A case report of primary gastric choriocarcinoma (in Japanese with English abstract), J Wakayama Med Soc, 46, pp. 213-7, (1995)

[20]

Imai Y., Kawabe T., Takahashi M., Matsumura M., Komatsu Y., Hamada E., A case of primary gastric choriocarcinoma and a review of the Japanese literature, J Gastroenterol, 29, pp. 642-6, (1994)

← 1 2 3 4 →