Primary gastric choriocarcinoma: Two case reports and a pooled analysis of 53 cases

被引：46
作者：
Kobayashi A. [1 ,3 ]
Hasebe T. [1 ]
Endo Y. [1 ]
Sasaki S. [2 ]
Konishi M. [3 ]
Sugito M. [3 ]
Kinoshita T. [3 ]
Saito N. [3 ]
Ochiai A. [1 ]
机构：
[1] Pathology Division, National Cancer Center Research Institute East, Kashiwa, Chiba 277-8577
[2] Epidemiology and Biostatistics Division, National Cancer Center Research Institute East, Kashiwa
[3] Department of Surgery, National Cancer Center Hospital East, Kashiwanoha, Kashiwa
来源：
Gastric Cancer | 2005年 / 8卷 / 3期
关键词：
Choriocarcinoma; Prognosis; Stomach;
D O I：
10.1007/s10120-005-0332-9
中图分类号：
学科分类号：
摘要：
Primary gastric choriocarcinoma (PGC) is a rare tumor. In total, approximately 140 cases of PGC have been reported in the international medical literature. However, the clinical behavior, tumor characteristics, and prognostic parameters of PGC have not been clearly described. We conducted a pooled analysis to clarify the tumor characteristics and prognostic parameters in 53 patients with PGCs, including 2 patients treated at our hospital. The following variables were examined as potential prognostic factors: (1) sex, (2) age, (3) depth of invasion, (4) size, (5) histology, (6) nodal metastasis, (7) distant lymph node metastasis, (8) synchronous liver metastasis, (9) residual tumor, and (10) chemotherapy (not given or given). Univariate and multivariate analyses showed that the presence of residual tumor and synchronous liver metastasis and the absence of chemotherapy were significantly associated with an increased hazard rate (HR) of short overall survival (OS). Pooled analysis, including the two patients with PGC treated at our facility, demonstrated that the presence of a curative operation and chemotherapy, and the absence of synchronous liver metastasis were the strongest indicators of a favorable clinical course in patients with PGC. © 2005 by International and Japanese Gastric Cancer Associations.
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页码：178 / 185
页数：7
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