Effects of steroid on the healing of colonic anastomoses in the rat

被引：14

作者：

Mantzoros I. ^{[1
]}

Kanellos I. ^{[1
,2
]}

Demetriades H. ^{[1
]}

Christoforidis E. ^{[1
]}

Kanellos D. ^{[1
]}

Pramateftakis M.G. ^{[1
]}

Zaraboukas T. ^{[1
]}

Betsis D. ^{[1
]}

机构：

[1] 4th Surgical Department, Aristotle University, Thessaloniki

[2] Panorama 55236, Thessaloniki

来源：

Techniques in Coloproctology | 2004年 / 8卷 / Suppl 1期

关键词：

Colonic anastomoses; Corticosteroid;

D O I：

10.1007/s10151-004-0150-9

中图分类号：

学科分类号：

摘要：

Background: The aim of this experimental study was to evaluate the effects of steroid on colonic anastomosis in a rat model. Methods: Forty female Wistar rats were randomised into two groups. After resection of a 1-cm segment of the transverse colon, an end-to-end sutured anastomosis was performed. In the rats of the control group 2 ml of solution 0.9% NaCl was injected once daily intraperitoneally perioperatively. Rats of the steroid group received intraperitoneally once daily, and on the same perioperative days, hydrocortisone (5 mg/kg body weight in 2 ml solution NaCl). All the rats were sacrificed on the 8th postoperative day and the anastomoses were examined macroscopically. The bursting pressure measurements were recorded and anastomoses were graded histologically. Results: Dehiscence rate was significantly higher in the steroid group than in the control group (p<0.001). Mean bursting pressure was significantly lower in the steroid group compared to the control group (p<0.001). Colonic healing process assessed as inflammatory cell infiltration and collagen deposition was significantly lower in the steroid group than in the control group (p<0.001, p=0.03 respectively). Conclusions: Perioperative steroid treatment adversely affects healing of colonic anastomoses in the rat.

引用

页码：S180 / S183

页数：3

共 12 条

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