Prevalence and correlates of vitamin K deficiency in children with inflammatory bowel disease

被引：0

作者：

Jan K. Nowak

Urszula Grzybowska-Chlebowczyk

Piotr Landowski

Anna Szaflarska-Poplawska

Beata Klincewicz

Daria Adamczak

Tomasz Banasiewicz

Andrzej Plawski

Jaroslaw Walkowiak

机构：

[1] Poznan University of Medical Sciences,Department of Pediatric Gastroenterology and Metabolic Diseases

[2] Medical University of Silesia,Department of Paediatrics

[3] Pediatric Gastroenterology,Medical University of Gdansk, Department of Pediatrics

[4] Hepatology and Nutrition,Department of Pediatric Endoscopy and Gastrointestinal Function Testing

[5] Nicolaus Copernicus University,Department of General

[6] Ludwik Rydygier Collegium Medicum in Bydgoszcz,undefined

[7] Poznan University of Medical Sciences,undefined

[8] Poznan University of Medical Sciences,undefined

[9] Gastroenterological and Endocrinological Surgery,undefined

[10] Institute of Human Genetics,undefined

[11] Polish Academy of Sciences,undefined

来源：

Scientific Reports | / 4卷

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摘要：

Although vitamin K deficiency has been implicated in adult inflammatory bowel disease (IBD), its prevalence in pediatric IBD remains unknown. We carried out a cross-sectional study in 63 children with Crohn's disease (CD) and 48 with ulcerative colitis (UC) to assess the prevalence of vitamin K deficiency and to search for potential correlation between vitamin K status and pediatric IBD activity. Vitamin K status was assessed using protein induced by vitamin K absence-II (PIVKA-II; ELISA). Prevalence of vitamin K deficiency was 54.0% in CD and 43.7% in UC. Vitamin K deficiency was more common in patients with higher CD activity, in CD patients with higher mass Z-scores and less common among children with CD treated with infliximab. Relation of vitamin K deficiency to pediatric IBD clinical course and treatment demand further research.

引用

共 49 条

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