Phase II trial of everolimus in patients with refractory metastatic adenocarcinoma of the esophagus, gastroesophageal junction and stomach: possible role for predictive biomarkers

被引:0
作者
Zev A. Wainberg
Heloisa P. Soares
Ravi Patel
Brian DiCarlo
David J. Park
Andre Liem
He-jing Wang
Lisa Yonemoto
Diego Martinez
Isett Laux
Meghan Brennan
J. Randolph Hecht
机构
[1] David Geffen School of Medicine at University of California,Division of Hematology/Oncology, Department of Medicine
[2] Los Angeles (UCLA),Department of Biomathematics
[3] Translational Research In Oncology - US (TRIO-US),undefined
[4] Comprehensive Blood and Cancer Center,undefined
[5] Coastal Integrative Cancer Center,undefined
[6] St. Jude Crosson Cancer Institute,undefined
[7] Pacific Shores Medical Group,undefined
[8] David Geffen School of Medicine at University of California,undefined
[9] Los Angeles (UCLA),undefined
来源
Cancer Chemotherapy and Pharmacology | 2015年 / 76卷
关键词
Gastric cancer; Everolimus; mTOR; Biomarkers;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:61 / 67
页数:6
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[1]  
Thuss-Patience PC(2011)Survival advantage for irinotecan versus best supportive care as second-line chemotherapy in gastric cancer—a randomised phase III study of the Arbeitsgemeinschaft Internistische Onkologie (AIO) Eur J Cancer 47 2306-2314
[2]  
Kretzschmar A(2014)Docetaxel versus active symptom control for refractory oesophagogastric adenocarcinoma (COUGAR-02): an open-label, phase 3 randomised controlled trial Lancet Oncol 15 78-86
[3]  
Bichev D(2012)Salvage chemotherapy for pretreated gastric cancer: a randomized phase III trial comparing chemotherapy plus best supportive care with best supportive care alone J Clin Oncol 30 1513-1518
[4]  
Deist T(2013)Gastric cancer-molecular and clinical dimensions Nat Rev Clin Oncol 10 643-655
[5]  
Hinke A(2010)Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial Lancet 376 687-697
[6]  
Breithaupt K(2010)The PI3 K pathway as drug target in human cancer J Clin Oncol 28 1075-1083
[7]  
Dogan Y(2009)Targeting PI3 K signalling in cancer: opportunities, challenges and limitations Nat Rev Cancer 9 550-562
[8]  
Gebauer B(2014)The role of PI3 K/Akt/mTOR signaling in gastric carcinoma Cancers 6 1441-1463
[9]  
Schumacher G(2009)Relation between outcomes and localisation of p-mTOR expression in gastric cancer Br J Cancer 100 782-788
[10]  
Reichardt P(2009)Overexpression of phosphorylated mammalian target of rapamycin predicts lymph node metastasis and prognosis of chinese patients with gastric cancer Clin Cancer Res 15 1821-1829