Efficacy and safety of rebamipide liquid for chemoradiotherapy-induced oral mucositis in patients with head and neck cancer: a multicenter, randomized, double-blind, placebo-controlled, parallel-group phase II study

被引：0
作者：
T. Yokota
T. Ogawa
S. Takahashi
K. Okami
T. Fujii
K. Tanaka
S. Iwae
I. Ota
T. Ueda
N. Monden
K. Matsuura
H. Kojima
S. Ueda
K. Sasaki
Y. Fujimoto
Y. Hasegawa
T. Beppu
H. Nishimori
S. Hirano
Y. Naka
Y. Matsushima
M. Fujii
M. Tahara
机构：
[1] Shizuoka Cancer Center,Division of Gastrointestinal Oncology
[2] Tohoku University Graduate School of Medicine,Department of Otolaryngology
[3] The Cancer Institute Hospital of JFCR,Head and Neck Surgery
[4] Tokai University,Department of Medical Oncology
[5] Osaka Medical Center for Cancer and Cardiovascular Diseases,Department of Otolaryngology, Center of Head and Neck Surgery
[6] Kindai University Faculty of Medicine,Department of Otolaryngology, Head and Neck Surgery
[7] Hyogo Cancer Center,Department of Medical Oncology
[8] Nara Medical University,Department of Head and Neck Cancer
[9] Hiroshima University Hospital,Department of Otolaryngology
[10] Shikoku Cancer Center,Head and Neck Surgery
[11] Miyagi Cancer Center,Department of Otorhinolaryngology
[12] Jikei University School of Medicine,Head and Neck Surgery
[13] Nara Hospital,Department of Head and Neck Surgery
[14] Kindai University School of Medicine,Department of Head and Neck Surgery
[15] Chiba Cancer Center,Department of Otorhinolaryngology
[16] Nagoya University,Medical Oncology
[17] Graduate School of Medicine,Head and Neck
[18] Aichi Cancer Center Hospital and Research Institute,Department of Otorhinolaryngology
[19] Saitama Cancer Center,Department of Head and Neck Surgery
[20] Okayama University Hospital,Division of Head and Neck Surgery
[21] Kyoto University Hospital,Department of Hematology and Oncology
[22] Eiju General Hospital,Department of Otolaryngology
[23] National Cancer Center Hospital East,Head and Neck Surgery
来源：
BMC Cancer | / 17卷
关键词：
Chemoradiotherapy; Head and neck cancer; Oral mucositis; Rebamipide liquid; Randomized; Placebo-controlled;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 89 条
[1]  
Lalla RV(2014)MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy Cancer 120 1453-1461
[2]  
Bowen J(2015)Oral mucositis induced by anticancer therapies Curr Oral Health Rep 2 202-211
[3]  
Barasch A(2004)Chemotherapy-induced and/or radiation therapy-induced oral mucositis--complicating the treatment of cancer Neoplasia 6 423-431
[4]  
Elting L(2011)Palifermin reduces severe mucositis in definitive chemoradiotherapy of locally advanced head and neck cancer: a randomized, placebo-controlled study J Clin Oncol 29 2808-2814
[5]  
Epstein J(2011)Palifermin decreases severe oral mucositis of patients undergoing postoperative radiochemotherapy for head and neck cancer: a randomized, placebo-controlled trial J Clin Oncol 29 2815-2820
[6]  
Keefe D(1985)Studies on 2(1H)-quinolinone derivatives as gastric antiulcer active agents. 2-(4-Chlorobenzoylamino)-3-[2(1H)-quinolinon-4-yl]propionic acid and related compounds Chem Pharm Bull 33 3775-3786
[7]  
Al-Ansari S(1992)Antiulcer mechanism of action of rebamipide, a novel antiulcer compound, on diethyldithiocarbamate-induced antral gastric ulcers in rats Eur J Pharmacol 212 9-13
[8]  
Zecha JA(1995)Hydroxyl radical scavenging by rebamipide and related compounds: electron paramagnetic resonance study Free Radic Biol Med 18 117-123
[9]  
Barasch A(1998)Rebamipide: overview of its mechanisms of action and efficacy in mucosal protection and ulcer healing Dig Dis Sci 43 5S-13S
[10]  
de Lange J(1999)Inhibitory effect of rebamipide on the neutrophil adherence stimulated by conditioned media from helicobacter pylori-infected gastric epithelial cells J Pharmacol Exp Ther 288 133-138
123456789