One-step arthroscopic technique for the treatment of osteochondral lesions of the knee with bone-marrow-derived cells: Three years results

被引：45

作者：

Buda R. ^{[1
]}

Vannini F. ^{[1
]}

Cavallo M. ^{[1
]}

Baldassarri M. ^{[1
]}

Luciani D. ^{[1
]}

Mazzotti A. ^{[1
]}

Pungetti C. ^{[1
]}

Olivieri A. ^{[1
]}

Giannini S. ^{[1
]}

机构：

[1] Clinical Orthopaedic and Traumatology Unit i, Rizzoli Orthopaedic Institute, Bologna

来源：

MUSCULOSKELETAL SURGERY | 2013年 / 97卷 / 2期

关键词：

Arthroscopic; Bone marrow; Knee; Mesenchymal; Osteochondral lesion; Stem cells;

D O I：

10.1007/s12306-013-0242-7

中图分类号：

学科分类号：

摘要：

Osteochondral lesions of the knee (OLK) are a common cause of knee pain and associated diseases. A new bone-marrow-derived mesenchymal stem cells technique has been developed for the treatment of OLK. 30 patients with OLK underwent arthroscopic one-step procedure. The bone marrow was harvested from the patients' posterior iliac crest and arthroscopically implanted with a scaffold into the lesion site. Clinical inspection and MRI were performed. Mean International Knee Documentation Committee (IKDC) score before surgery was 29.9 ± 13.2 and 85.4 ± 4.2 at 29 ± 4.1 months (p < 0.0005), while Knee injury and Osteoarthritis Outcome Score (KOOS) before surgery was 35.1 ± 11.9 and 87.3 ± 7.3 at 29 ± 4.1 months (p < 0.0005). Control MRI and bioptic samples showed an osteochondral regeneration of the lesion site. The one-step technique appears to be a good and reliable option for treatment of OLK at three years of follow-up. Level of evidence Case series, Level IV. © 2013 Istituti Ortopedici Rizzoli.

引用

页码：145 / 151

页数：6

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