Synthesis, antibacterial and antiproliferative potential of some new 1-pyridinecarbonyl-4-substituted thiosemicarbazide derivatives

被引：0
作者：
Monika Pitucha
Maciej Woś
Malgorzata Miazga-Karska
Katarzyna Klimek
Barbara Mirosław
Anna Pachuta-Stec
Agata Gładysz
Grazyna Ginalska
机构：
[1] Medical University,Department of Organic Chemistry
[2] Medical University,Chair and Department of Biochemistry and Biotechnology
[3] Maria Curie-Sklodowska University,Department of Crystallography, Faculty of Chemistry
[4] Medical University of Lublin,Department of Medicinal Chemistry
来源：
Medicinal Chemistry Research | 2016年 / 25卷
关键词：
Thiosemicarbazide; Antibacterial activity; Cytotoxicity; Cell proliferation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In this study, the antibacterial, cytotoxic and antiproliferative activities of novel thiosemicarbazide derivatives were assessed. Our results demonstrated that some of the novel compounds possess good antibacterial properties against Staphylococcus epidermidis, Streptococcus mutans and Streptococcussanguinis and are only slightly cytotoxic; thus, they exhibit an excellent therapeutic index, which is higher than that of ethacridine lactate. Moreover, our data showed that compounds 2 and 4 have an antiproliferative activity against human breast adenocarcinoma and human hepatocellular carcinoma cell lines. We expect that the novel thiosemicarbazide derivatives can be used as agents for treatment of dental caries and also for chemotherapy support.
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页码：1666 / 1677
页数：11
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