Sensitive 13C–13C correlation spectra of amyloid fibrils at very high spinning frequencies and magnetic fields

被引：0
作者：
Markus Weingarth
Yuichi Masuda
K. Takegoshi
Geoffrey Bodenhausen
Piotr Tekely
机构：
[1] Ecole Normale Supérieure,Département de Chimie
[2] Université Pierre et Marie Curie,Département de Chimie
[3] CNRS,Department of Chemistry, Graduate School of Science
[4] UMR 7203,undefined
[5] Utrecht University,undefined
[6] Kyoto University,undefined
来源：
Journal of Biomolecular NMR | 2011年 / 50卷
关键词：
Amyloid β fibrils; Solid-state NMR; C–; C 2D correlation spectra; Dipolar truncation; PARIS-xy dipolar recoupling; Ultra-high magnetic field;
D O I：
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中图分类号：
学科分类号：
摘要：
Sensitive 2D solid-state 13C–13C correlation spectra of amyloid β fibrils have been recorded at very fast spinning frequencies and very high magnetic fields. It is demonstrated that PARIS-xy recoupling using moderate rf amplitudes can provide structural information by promoting efficient magnetization transfer even under such challenging experimental conditions. Furthermore, it has been shown both experimentally and by numerical simulations that the method is not very sensitive to dipolar truncation effects and can reveal direct transfer across distances of about 3.5–4Å.
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页码：129 / 136
页数：7
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