Viral pathogens in acute exacerbations of chronic obstructive pulmonary disease

被引：0
作者：
Carlos A. Camargo
Adit A. Ginde
Sunday Clark
Charles P. Cartwright
Ann R. Falsey
Dennis E. Niewoehner
机构：
[1] Massachusetts General Hospital,Department of Emergency Medicine
[2] Harvard Medical School,Department of Emergency Medicine
[3] University of Colorado Denver School of Medicine,Department of Emergency Medicine
[4] Beth Israel Deaconess Medical Center,Division of General Internal Medicine
[5] University of Pittsburgh,Department of Laboratory Medicine and Pathology
[6] Hennepin County Medical Center,Department of Medicine
[7] University of Rochester,Pulmonary Section
[8] Veterans Affairs Medical Center,EMNet Coordinating Center
[9] Massachusetts General Hospital,undefined
来源：
Internal and Emergency Medicine | 2008年 / 3卷
关键词：
COPD; Exacerbation; Virus; Infection; Pulmonary; Emergency department;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The objective of this study is to determine the prevalence of respiratory syncytial virus (RSV) and other viral respiratory pathogens in emergency department (ED) patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD). COPD patients presenting to the ED with <10 days of AECOPD symptoms were eligible. We used PCR to test nasal swabs for common viral respiratory pathogens. We completed viral studies on 76 patients from two EDs. Patients had a mean age of 72 years, and were 68% male, 99% white, and 29% current smokers. Influenza vaccination was reported by 87%. Viruses were detected in 19 of 76 patients (25%). These included RSV A (2) and B (4); parainfluenza 1 (1), 2 (0), and 3 (2); influenza A (3) and B (0); rhinovirus (4); and human metapneumovirus (3). A putative viral etiology was identified in 25% of AECOPD presenting for emergency care, of which approximately one-third were RSV-related.
引用
收藏
相关论文
共 90 条
[1]  
Mannino DM(2002)Chronic obstructive pulmonary disease surveillance—United States, 1971–2000 MMWR 51 1-16
[2]  
Homa DM(2008)Viral infections in patients with chronic obstructive pulmonary disease Curr Opin Pulm Med 14 89-94
[3]  
Akinbami LJ(2002)Respiratory syncytial virus infections in children and adults J Infect 45 10-17
[4]  
Ford ES(2005)Respiratory syncytial virus infection in elderly and high-risk adults N Engl J Med 352 1749-1759
[5]  
Redd SC(2006)The association of respiratory syncytial virus infection and influenza with emergency admissions for respiratory disease in London: an analysis of routine surveillance data Clin Infect Dis 42 640-646
[6]  
Varkey JB(1973)Respiratory viral infections in hospital patients with chronic bronchitis Chest 63 336-341
[7]  
Varkey B(2000)Respiratory viral infections in adults with and without chronic obstructive pulmonary disease Am J Respir Crit Care Med 162 167-173
[8]  
Collins CL(2001)Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease Am J Respir Crit Care Med 164 1618-1623
[9]  
Pollard AJ(2003)Respiratory viruses in exacerbations of chronic obstructive pulmonary disease requiring hospitalisation: a case-control study Thorax 58 37-42
[10]  
Falsey AR(2006)Human metapneumovirus and exacerbations of chronic obstructive pulmonary disease J Infect 53 248-254
123456789