Neocitreamicins I and II, Novel Antibiotics with Activity against Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci

被引：0
作者：
Aaron J Peoples
Qibo Zhang
William P Millett
Mithra T Rothfeder
Brian C Pescatore
Anne A Madden
Losee L Ling
Charles M Moore
机构：
[1] NovoBiotic Pharmaceuticals,
来源：
The Journal of Antibiotics | 2008年 / 61卷
关键词：
neocitreamicin; citreamicin; MRSA; VRE;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Two novel antibiotics, neocitreamicins I and II, were isolated from a fermentation broth of a Nocardia strain. This producing strain was obtained using an in situ diffusion chamber that facilitates the cultivation of soil microorganisms. The structures of neocitreamicins I and II were elucidated using UV, MS, and NMR data, and found to be related to the polycyclic xanthone antibiotics of the citreamicin class. The neocitreamicins showed in vitro activity against Gram-positive bacteria including strains of methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis.
引用
收藏
页码：457 / 463
页数：6
相关论文
共 56 条
[1]  
Maiese WM(1989)LL-E19085 alpha, a novel antibiotic from Micromonospora citrea: taxonomy, fermentation and biological activity J Antibiot 42 846-851
[2]  
Lechevalier MP(1990)Citreamicins, novel antibiotics from J Antibiot 43 504-512
[3]  
Lechevalier HA(1991): isolation, characterization, and structure determination J Antibiot 44 1247-1251
[4]  
Korshalla J(1982)The effect of methylation inhibitors on citreamicin biosynthesis in J Antibiot 35 645-652
[5]  
Goodman J(1989)Cervinomycin A1 and A2, new antibiotics active against anaerobes, produced by J Chem Soc Commun 1989 1771-1772
[6]  
Wildey MJ(1988) sp. nov J Antibiot 41 502-511
[7]  
Kuck N(1988)Structure determination of simaomicin α and β, extremely potent, novel anticoccidial agents produced by Actinomadura J Antibiot 41 502-511
[8]  
Greenstein M(2002)Actinoplanones A and B, new cytotoxic polycyclic xanthones from Science 296 1127-1129
[9]  
Carter GT(2003) sp J Microbiol Meth 55 541-555
[10]  
Nietsche JA(1966)Actinoplanones C, D, E, F, and G, new cytotoxic polycyclic xanthones from Int J Syst Bacteriol 16 313-340
123456