Genetic analysis for rs2280205 (A>G) and rs2276961 (T>C) in SLC2A9 polymorphism for the susceptibility of gout in Cameroonians: A pilot study

被引：1

作者：

Nkeck J.R. ^{[1
]}

Ngandeu M.S. ^{[1
,2
]}

Moor V.A. ^{[1
,3
]}

Nkeck J.P. ^{[1
]}

Chedjou J.-P. ^{[4
]}

Ndoadoumgue A.L. ^{[5
]}

Mbacham W.F. ^{[1
,4
]}

机构：

[1] Faculty of Medicine and Biomedical Sciences, University of Yaoundé i, Yaoundé

[2] Rheumatology Unit, Yaoundé Central Hospital, Yaoundé

[3] Biochemistry Laboratory of the Yaoundé, University Hospital Centre, Yaoundé

[4] Laboratory of Public Health Biotechnology, Biotechnology Centre, University of Yaoundé i, Yaoundé

[5] School of Health and Related Research, University of Sheffield, Sheffield

来源：

BMC Research Notes | / 11卷 / 1期

关键词：

Genetic; Gout; Non-synonymous variants; rs2276961; rs2280205; SLC2A9;

D O I：

10.1186/s13104-018-3333-6

中图分类号：

学科分类号：

摘要：

Objective: To determine the association of non-synonymous variants rs2280205 and rs2276961 of the SLC2A9 gene to gout in Cameroonians. Results: In a case-control study including 30 patients with acute gout matched to 30 healthy volunteers. We searched for polymorphism of the targeted variants using Restriction Fragment Length Polymorphism following polymerize chain reaction. Fisher exact test and Student t-test were used to compare variables, with a threshold of significance set at 0.05. The mean age of participants was 58 ± 8 years with 28 (93%) males. The family history of gout was found in one-third of the cases (p > 0.05). Uricemia was higher in cases than controls (p < 0.001) but 24 h urate excretion was similar in both groups (p > 0.05). Ancestral alleles (G and C) and their homozygous genotypes (GG and CC) of the targeted variants were predominant in both groups (p < 0.001). The polymorphisms of targeted variants were not associated with gout, and do not influence uric acid concentration in blood and urine. Non-synonymous variants rs2280205 and rs2276961 are not associated with gout in Cameroonians. However, the hereditary component of the disease suggests the influence of other genetic and/or environmental factors. © 2018 The Author(s).

引用

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