Analysis of EEG structural synchrony in adolescents with schizophrenic disorders

被引：23

作者：

Borisov S.V. ^{[1
]}

Kaplan A.Ya. ^{[1
]}

Gorbachevskaya N.L. ^{[2
]}

Kozlova I.A. ^{[2
]}

机构：

[1] Moscow State University

[2] Mental Health Research Center, Russian Academy of Medical Sciences, Moscow

来源：

Human Physiology | 2005年 / 31卷 / 3期

基金：

俄罗斯基础研究基金会;

关键词：

Schizophrenic Disorder; Human Physiology; Electrical Activity; Operational Activity; Neuronal Network;

D O I：

10.1007/s10747-005-0042-z

中图分类号：

学科分类号：

摘要：

A total of 39 healthy adolescents and 45 adolescents with schizophrenic disorders (mean age 12.3 years) were examined to study the EEG structural synchrony as reflecting temporal synchronization of the operational activity of neuronal networks. A significant decrease in the EEG structural synchrony was observed in the adolescents with schizophrenic disorders as compared to the healthy adolescents. The decrease was detected predominantly in the interhemispheric pairs of EEG derivations, as well as in the pairs related to the frontal, temporal (predominantly on the left), and right parietocentral regions. The findings provide evidence in favor of Friston's hypothesis of disintegration of cortical electrical activity in schizophrenia and extend the hypothesis in that it is the operational synchrony of cortical activity that might suffer first in schizophrenia. © 2005 MAIK "Nauka/Interperiodica".

引用

页码：255 / 261

页数：6

共 42 条

[1]

Selemon L.D., Goldman-Rakis P.S., The Reduced Neuropil Hypothesis: A Circuit-Based Model of Schizophrenia, Biol. Psychiatry, 45, (1999)

[2]

Benes F.M., Emerging Principles of Altered Neural Circuitry in Schizophrenia, Brain Res. Rev., 31, (2000)

[3]

Lewis D.A., Gonzalez-Burgos G., Intrinsic Excitatory Connections in the Prefrontal Cortex and the Pathophysiology of Schizophrenia, Brain Res. Bull., 52, (2000)

[4]

Alfimova M.V., Uvarova L.G., Trubnikov V.I., Electroencephalography and Cognitive Processes in Schizophrenia, Zh. Nevropatol. Psikhiatr. Im. S.S. Korsakova, 98, 11, (1998)

[5]

Sponheim S.R., Clementz B.A., Iacono W.G., Beiser M., Clinical and Biological Concomitants of Resting State EEG Power Abnormalities in Schizophrenia, Biol. Psychiatry, 48, (2000)

[6]

Mann K., Maier W., Franke P., Et al., Intra-and Interhemispheric Electroencephalogram Coherence in Siblings Discordant for Schizophrenia and Healthy Volunteers, Biol. Psychiatry, 42, 8, (1997)

[7]

Tauscher J., Fischer P., Neumeister A., Et al., Low Frontal Electroencephalographic Coherence in Neuroleptic-Free Schizophrenic Patients, Biol. Psychiatry, 44, 6, (1998)

[8]

Strelets V.B., Novototskii-Vlasov V.Yu., Golikova Zh.V., Cortical Relations in Schizophrenic Patients with Positive or Negative Symptoms, Zh. Vyssh. Nervn. Deyat., 51, 4, (2001)

[9]

Breakspear M., Terry J.R., Friston K.J., Et al., A Disturbance of Nonlinear Interdependence in Scalp EEG of Subjects with First Episode Schizophrenia, Neuroimage, 20, 1, (2003)

[10]

Spencer K.M., Nestor P.G., Niznikiewicz M.A., Et al., Abnormal Neural Synchrony in Schizophrenia, J. Neurosci., 23, 19, (2003)

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