Modification of biologically active amides and amines with fluoro-containing heterocycles 5. Fluoro-containing heterocyclic derivatives of 2-amino-1,3,4-thiadiazoles

被引：0
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作者：
V. B. Sokolov
A. Yu. Aksinenko
T. A. Epishina
T. V. Goreva
I. V. Martynov
机构：
[1] Russian Academy of Sciences,Institute of Physiologically Active Compounds
来源：
Russian Chemical Bulletin | 2011年 / 60卷
关键词：
2-amino-1,3,4-thiadiazoles; methyl trifluoropyruvate; 1,3,4-thiadiazol-2-ylimines; 6-aminouracils; 6-aminothiouracils; N-substituted 3-aminocyclohexenones; N-sub-stituted ureas; N-substituted benzamidines; 3-aminocrotononitrile; fluoro-containing dihydro-1; -pyrroles; hexahydro-1; -indoles; hexahydro-1; -pyrrolo[2,3-; ]pyrimidines, imidazolidine-2,4-diones, cyclocondensation;
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摘要：
An approach to modification of biologically active 2-amino-1,3,4-thiadiazoles with fluoro-containing five-membered heterocycles was proposed. The approach involves reactions of imines (generated in situ from 2-amino-1,3,4-thiadiazoles and methyl trifluoropyruvate) with 1,3-binucleophiles such as 6-aminouracils, 6-aminothiouracils, N-substituted 3-aminocyclohexenones, N-substituted ureas, N-substituted benzamidines, and 3-aminocrotononitrile.
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页码：707 / 711
页数：4
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