Role of Mediator in virulence and antifungal drug resistance in pathogenic fungi

被引：0
作者：
Gary P. Moran
Matthew Z. Anderson
Lawrence C. Myers
Derek J. Sullivan
机构：
[1] Dublin Dental University Hospital,Division of Oral Biosciences
[2] University of Dublin,School of Dental Science, Trinity College Dublin
[3] The Ohio State University,Department of Microbial Infection and Immunity
[4] Geisel School of Medicine at Dartmouth,Department of Medical Education
[5] Geisel School of Medicine at Dartmouth,Department of Biochemistry and Cell Biology
来源：
Current Genetics | 2019年 / 65卷
关键词：
Fungi; Pathogenicity; Antifungals; Resistance; Mediator; Transcription;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Mediator complex has recently emerged as an important regulator of gene expression in pathogenic fungi. Mediator is a multi-subunit complex of polypeptides involved in transcriptional activation in eukaryotes, with roles including preinitiation complex (PIC) assembly and chromatin remodeling. Within the last decade, Mediator has been shown to play an integral role in regulating virulence gene expression and drug resistance in human fungal pathogens. In some fungi, specific Mediator subunits have been shown to be required for virulence. In Candida species, duplication and expansion of Mediator subunit encoding genes has occurred on at least three occasions (CgMED15 in C. glabrata and MED2/TLO in C. albicans and C. dubliniensis) suggesting important roles for Mediator in the evolution of these pathogens. This review summarises recent developments in our understanding of Mediator in fungal pathogens and the potential for the development of therapeutic drugs to target Mediator functions.
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页码：621 / 630
页数：9
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共 397 条
[21]  
Carlisle PL(2018) gene family enhances the virulence of Curr Genet 64 883-1613
[22]  
Pierce C(2014) species PLoS Genet 10 e1004658-302
[23]  
Monteagudo C(2013)Sir2 regulates stability of repetitive domains differentially in the human fungal pathogen Mol Microbiol 90 22-44026
[24]  
Lopez-Ribot JL(2015)Mediator CDK subunits are platforms for interactions with various chromatin regulatory complexes Genome Res 25 413-106
[25]  
Kadosh D(2009)On the mechanism of constitutive Pdr1 activator-mediated PDR5 Transcription in PLoS Genet 5 e1000783-432
[26]  
Borah S(2009)Negative effect of the transcriptional activator GAL4 Genome Res 19 2231-27
[27]  
Shivarathri R(2017)Transcription factor network efficiency in the regulation of Candida albicans biofilms: it is a small world Trends Cell Biol 64 455-489
[28]  
Srivastava VK(2016)Telomeric ORFs (TLOs) in Mol Cell 6 6757-e14
[29]  
Ferrari S(2015) spp. encode mediator subunits that regulate distinct virulence traits Nat Comm 48 1600-197
[30]  
Sanglard D(2004)Structure of the transcriptional network controlling white-opaque switching in Antimicrob Agents Chemother 83 1-e1001515
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